Browsing by Author "Blom, HJ"
Now showing 1 - 6 of 6
Results Per Page
Sort Options
- 5,10-methylenetetrahydrofolate reductase (MTHFR) 677C - T and 1298A - C mutations are associated with DNA hypomethylationPublication . Castro, R; Rivera, I; Ravasco, P; Camilo, ME; Jakobs, C; Blom, HJ; de Almeida, IT
- 5,10-Methylenetetrahydrofolate reductase 677C - T and 1298A - C mutations are genetic determinants of elevated homocysteinePublication . Castro, R; Rivera, I; Ravasco, P; Jakobs, C; Blom, HJ; Camilo, ME; de Almeida, ITBackground: Methylenetetrahydrofolate reductase (MTHFR) is one of the main regulatory enzymes of homocysteine metabolism. Elevated plasma total homocysteine (tHcy) is a major risk for cardiovascular disease. A common 677C--T mutation in the MTHFR gene re
- Increased, homocysteine and S-adenosylhomocysteine concentrations and DNA hypomethylation in vascular diseasePublication . Castro, R; Rivera, I; Struys, EA; Jansen, EEW; Ravasco, P; Camilo, ME; Blom, HJ; Jakobs, C; de Almeida, ITBackground: The pathogenic mechanism of homocysteine's effect on cardiovascular risk is poorly understood. Recent studies show that DNA hypomethylation induced by increases in S-adenosylhomocysteine (AdoHcy), an intermediate of Hcy metabolism and a potent
- Intracellular S-adenosylhomocysteine increased levels are associated with DNA hypomethylation in HUVECPublication . Castro, R; Rivera, I; Martins, C; Struys, EA; Jansen, EEW; Clode, N; Graca, LM; Blom, HJ; Jakobs, C; de Almeida, ITHyperhomocysteinemia is a risk factor for atherosclerosis and vascular disease; however, the mechanism underlying this association remains poorly understood. Increased levels of intracellular S-adenosylhomocysteine (AdoHcy), secondary to homocysteine-medi
- Molecular genetic analysis of the cystathionine beta-synthase gene in Portuguese homocystinuria patientsPublication . Castro, R; Heil, SG; Rivera, I; Jakobs, C; de Almeida, IT; Blom, HJ
- Quantification of plasma S-adenosylmethionine and S-adenosylhomocysteine as their fluorescent 1,N-6-etheno derivativesPublication . Castro, R; Struys, EA; Jansen, EEW; Blom, HJ; de Almeida, IT; Jakobs, CA simplified reversed phase HPLC system for the detection of fluorescent 1,N-6-etheno derivatives of SAM (S-adenosylmethionine) and S-adenosylhomocysteine (SAH) is described. The most important changes from the previously reported method are a shorter der