Increased, homocysteine and S-adenosylhomocysteine concentrations and DNA hypomethylation in vascular disease

Castro, R; Rivera, I; Struys, EA; Jansen, EEW; Ravasco, P; Camilo, ME; Blom, HJ; Jakobs, C; de Almeida, IT

http://hdl.handle.net/10451/21242

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Abstract(s)

Background: The pathogenic mechanism of homocysteine's effect on cardiovascular risk is poorly understood. Recent studies show that DNA hypomethylation induced by increases in S-adenosylhomocysteine (AdoHcy), an intermediate of Hcy metabolism and a potent