5,10-Methylenetetrahydrofolate reductase 677C - T and 1298A - C mutations are genetic determinants of elevated homocysteine

Castro, R; Rivera, I; Ravasco, P; Jakobs, C; Blom, HJ; Camilo, ME; de Almeida, IT

http://hdl.handle.net/10451/21241

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Background: Methylenetetrahydrofolate reductase (MTHFR) is one of the main regulatory enzymes of homocysteine metabolism. Elevated plasma total homocysteine (tHcy) is a major risk for cardiovascular disease. A common 677C--T mutation in the MTHFR gene re