Intracellular S-adenosylhomocysteine increased levels are associated with DNA hypomethylation in HUVEC

Castro, R; Rivera, I; Martins, C; Struys, EA; Jansen, EEW; Clode, N; Graca, LM; Blom, HJ; Jakobs, C; de Almeida, IT

http://hdl.handle.net/10451/21244

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Abstract(s)

Hyperhomocysteinemia is a risk factor for atherosclerosis and vascular disease; however, the mechanism underlying this association remains poorly understood. Increased levels of intracellular S-adenosylhomocysteine (AdoHcy), secondary to homocysteine-medi