FM-CCUL-Artigos em Revistas Nacionais
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- Acquired fistula from left anterior descending artery to coronary sinus : an unusual finding during percutaneous coronary interventionPublication . Francisco, Ana Rita G.; Menezes, Miguel Nobre de; Pinto, Fausto J.; Silva, Pedro Canas da
- Active fixation coronary sinus lead extraction : a safe procedurePublication . Guimarães, Tatiana; Silva, Gustavo Lima da; Bernardes, Ana; Sousa, João de; Marques, Pedro
- Acute coronay syndrome in a patient with severe hemophilia A: dificult decisionsPublication . Aguiar-Ricardo, Inês; Agostinho, João R.; Pereira, Artur; Rodrigues, Fatima; Brito, Dulce; Pinto, Fausto J.; Catarino, Cristina; Mendes Pedro, MónicaHemophilia A is an inherited coagulation disease characterized by factor VIII (FVIII) deficiency and is associated with high hemorrhagic risk, especially in its severe forms. As the average life expectancy of patients with hemophilia has increased, so has the prevalence of acute coronary events. There is however limited experience in dealing with them. The strategy of acting on acute coronary events in patients with hemophilia, as demonstrated in the present case, is a real challenge, not only due to the need for antiplatelet therapy (which is essential in the prevention of stent thrombosis, but increases hemorrhagic risk), but also due to the lack of specific recommendations related to the most adequate and safe replacement therapy in these situations. The authors describe the case of a 48-year-old man with unstable angina and a previous diagnosis of severe hemophilia A who underwent percutaneous coronary intervention under FVIII therapy without hemorrhagic complications.
- Acute type A aortic dissection in a patient with paragangliomaPublication . Borrego, Andreia dos Santos; Carrilho-Ferreira, Pedro; Pinto, Fausto J.Acute aortic dissection is the most common acute aortic syndrome. It is more prevalent in males and in the elderly, and has a high mortality. Hypertension is the main risk factor. Diagnosis is based on clinical features, laboratory tests and imaging exams. Treatment is usually surgical, although in some cases an endovascular approach is an alternative. Paraganglioma is an uncommon neuroendocrine tumor. Most produce catecholamines, and so usually manifest with hypertensive crisis, palpitations, headache and sweating. This tumor is diagnosed by measurement of plasma or urinary catecholamines and by computed tomography, magnetic resonance imaging and 123I-metaiodobenzylguanidine (MIBG) scintigraphy. Surgery is the only potentially curative treatment.
- Adjuvant antithrombotic therapy in ST-elevation myocardial infarction : a narrative reviewPublication . Caldeira, Daniel; Pereira, HelderThis article reviews the major pharmacologic features of, and clinical evidence on, adjuvant medical therapy in patients with ST-elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention. These drugs include oral antiplatelets (aspirin and P2Y12 inhibitors such as clopidogrel, prasugrel and ticagrelor), intravenous antiplatelet agents (the P2Y12 inhibitor cangrelor, GP IIb/IIIa inhibitors such as abciximab, eptifibatide and tirofiban), and intravenous anticoagulant agents (unfractionated heparin, low molecular weight heparin and bivalirudin).
- Adjuvant antithrombotic therapy in ST-elevation myocardial infarction : contemporaneous portuguese cross-sectional dataPublication . Caldeira, Daniel; Pereira, Hélder; Marques, Ana; Alegria, Sofia; Calisto, João; Canas da Silva, Pedro; Ribeiro, Vasco Gama; Silva, João Carlos; Seixo, Filipe; Abreu, Pedro Farto e; Teles, Rui Campante; Fernandes, Renato; Carvalho, Henrique CyrneIntroduction: The standard of care for acute ST-elevation myocardial infarction (STEMI) includes the activation of a STEMI care network, the administration of adjuvant medical therapy, and reperfusion through primary percutaneous coronary intervention (PCI). While primary PCI is nowadays the first option for the treatment of patients with STEMI, antithrombotic therapy, including antiplatelet and anticoagulant agents, is the cornerstone of pharmacological treatment to optimize their clinical outcomes. Objective: The aim of this study was to describe contemporaneous real-world patterns of use of antithrombotic treatments in Portugal for STEMI patients undergoing primary PCI. Methods: An observational, retrospective cross-sectional study was performed for the year 2016, based on data from two national registries: the Portuguese Registry on Acute Coronary Syndromes (ProACS) and the Portuguese Registry on Interventional Cardiology (PRIC). Data on oral antiplatelet and procedural intravenous antithrombotic drugs were retrieved. Results: In 2016, the ProACS enrolled 534 STEMI patients treated with primary PCI, while the PRIC registry reported data on 2625 STEMI patients. Of these, 99.6% were treated with aspirin and 75.6% with dual antiplatelet therapy (mostly clopidogrel). GP IIb/IIIa inhibitors (mostly abciximab) were used in 11.6% of cases. Heparins were used in 80% of cases (78% unfractionated heparin [UFH] and 2% low molecular weight heparin). None of the patients included in the registry were treated with cangrelor, prasugrel or bivalirudin. Missing data are one of the main limitations of the registries. Conclusions: In 2016, according to data from these national registries, almost all patients with STEMI were treated with aspirin and 76% with dual antiplatelet agents, mostly clopidogrel. GP IIb/IIIa inhibitors were used in few patients, and UFH was the most prevalent parenteral anticoagulant drug.
- Aerobic fitness questionnaires: still not enough to estimate VO2 peak in cardiac patients!Publication . Abreu, AnaThe present study by Lima et al. “Validation of an Aerobic Fitness Questionnaire to estimate VO2 peak in a cohort of adult cardiac patients – Is it enough?”, intends to validate the CLINIMEX Aerobic Fitness Questionnaire (C-AFQ),3 comprising a list of activities, in a Portuguese population sample of 124 CV patients (93% male, mean age 61 years old, 61% with heart failure), who were referred for CPET and cardiac rehabilitation. In this prospective study, which enrolled exclusively CV patients (mainly male), C-AFQ was not sufficiently accurate to predict functional capacity measured by VO2 peak. Despite a numerically strong and positive correlation between measured and estimated, by C-AFQ, VO2 peak (r=0.723, p<0.001), high levels of disagreement in the Bland–Altman plot analysis were observed.
- Always look at the sinus rhythm electrocardiogram in patients with ventricular tachycardiaPublication . Silva, Gustavo Lima da; Dias, Nuno Cortez; Neves, Irina; Almeida, Ana G.; Sousa, João de