Browsing by Author "Abreu, Pedro"
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- Antileishmanial activity of piceatannol isolated from Euphorbia lagascae seedsPublication . Duarte, Noelia; Kayser, Oliver; Abreu, Pedro; Ferreira, Maria-Jose U.In the search for biologically active compounds from Euphorbia lagascae Spreng, an herbaceous plant native to southeast of Iberic Peninsula, a stilbene, two coumarins and two 1-2-deoxyphorbol diterpene esters were isolated by chromatographic methods, from the methanol extracts of its defatted seeds. The structures of these compounds were elucidated by a combination of physical and spectral data (IR, MS and high-resolution H-1-NMR and C-13-NMR spectroscopy utilizing COSY, HMBC, HMQC and NOESY experiments). The stilbene, piceatannol, was screened for its antileishmanial activity against promastigotes as an extracellular form of Leishmania donovani, Leishmania infantum and Leishmania major, and amastigotes of Leishmania donovani as an intracellular form. Pentostan((R)) (sodium stibogluconate), the first line clinical drug, was used as a standard reference. Piceatannol was moderately active against the extracellular forms of the three tested Leishmania species, and more active than the reference compound against the intracellular form of Leishmania donovani. Copyright (c) 2007 John Wiley & Sons, Ltd.
- Estudo de Antecipação de Necessidades de Qualificações na Região OestePublication . Caeiro, Joaquim; Teles, Helena; Martins, João; Abreu, Pedro; Ramos, Rosária
- Estudo de Antecipação de Necessidades de Qualificações na Região OestePublication . Caeiro, Joaquim; Teles, Helena; Martins, João; Abreu, Pedro; Ramos, Rosária
- Recomendações sobre a abordagem da esclerose múltipla na gravidez, parto e pós-parto : posição de consenso do Grupo de Estudos de Esclerose MúltiplaPublication . Batista, Sónia; Martins da Silva, Ana; Sá, Maria José; Sousa, Lívia; De Sá, João; Pedrosa, Rui; Cerqueira, João; Pinheiro, Joaquim; Abreu, Pedro; Simões, Rita Moiron; Vale, JoséMultiple sclerosis typically affects young women of reproductive age. Therefore, all healthcare professionals involved in the follow-up of multiple sclerosis patients must be prepared to discuss pregnancy and breastfeeding issues and provide the best possible counselling. However, there are still many doubts and heterogeneous clinical approaches partly due to the lack of consensus and guidelines. Concerning the handling of disease modifying therapies during pregnancy and postpartum, existing uncertainties have been complicated by the increase in the number of treatments available in recent years. This article aims to present the state-of-the-art and provide guidance based on the best level of available evidence and expert opinion regarding the management of multiple sclerosis patients at different stages: pregnancy planning, pregnancy, partum, and the postpartum period.