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Authors
Abstract(s)
O carcinoma de células escamosas (CCE) é uma das neoplasias malignas mais
frequentes nos gatos, representando aproximadamente 15% das suas neoplasias cutâneas e
60-75% das neoplasias orais. A eletroquimioterapia (EQT) é uma modalidade de tratamento
oncológico recente que associa a administração de agentes quimioterápicos, não permeáveis
ou com baixa permeabilidade, com a aplicação localizada de pulsos elétricos
permeabilizadores. Os curtos pulsos elétricos de alta tensão resultam num aumento
substancial e transitório da permeabilidade das células neoplásicas (eletroporação) e a
citotoxicidade do agente quimioterápico aumenta por várias ordens de magnitude.
Recentemente a EQT tem vindo a ganhar popularidade na Oncologia Veterinária pela sua
elevada eficácia associada a baixa toxicidade. Este estudo retrospetivo teve como objetivo a
avaliação da eficácia da EQT com bleomicina como tratamento de CCE cutâneos e orais em
gatos. Quinze gatos com CCE na região da cabeça (13 CCE cutâneos e 2 CCE orais) foram
tratados com pelo menos uma sessão de EQT (entre dezembro de 2015 e novembro de 2016)
no Hospital Veterinário Berna. A resposta ao tratamento foi classificada às quatro semanas
após tratamento com base nos Critérios de Avaliação de Resposta em Neoplasias Sólidas
(RECIST) e os efeitos adversos foram avaliados e determinados de acordo com a escala de
toxicidade VCOG-CTCAE 2011. Verificou-se uma taxa de resposta objetiva global de 86%.
Dos catorze gatos nos quais foi possível a classificação da resposta, oito (57%) apresentaram
remissão completa, quatro (29%) remissão parcial e dois (14%) progressão da doença. O
tratamento foi bem tolerado e os efeitos adversos observados foram maioritariamente ligeiros
e transeuntes. Os resultados sugerem que a EQT é um tratamento eficaz de CCE em gatos,
especialmente dos CCE cutâneos em estádios iniciais ou com lesões de diâmetro inferior a 3
cm.
ABSTRACT - ELECTROCHEMOTHERAPY FOR THE TREATMENT OF SQUAMOUS CELL CARCINOMA IN CATS: RETROSPECTIVE STUDY - Squamous cell carcinoma (SCC) is one of the most common malignant tumours in cats, representing approximately 15% of its cutaneous tumours and 60-75% of oral tumours. Electrochemotherapy (ECT) is a recent cancer treatment modality that combines the administration of chemotherapeutic agents, non-permeable or with low permeability, with the localized application of permeabilizing electric pulses. Short high-voltage pulses result in a substantial and transient increased permeability of neoplastic cells (electroporation) and the cytotoxicity of the chemotherapeutic agent increases by several orders of magnitude. Recently, ECT has been gaining popularity in Veterinary Oncology due to its high effectiveness associated with low toxicity. This retrospective study aimed to evaluate the efficacy of ECT with bleomycin as a treatment for cutaneous and oral SCC in cats. Fifteen cats with SCC of the head region (13 cutaneous SCC and 2 oral SCC) were treated with at least one ECT session at Hospital Veterinário Berna, between December 2015 and November 2016. Response to treatment was assessed four weeks after completion of treatment based on the Solid Neoplasm Response Assessment Criteria (RECIST) and adverse effects were graded according to the VCOG-CTCAE 2011. The overall response rate was 86%. Of the fourteen cats in which it was possible to classify the response, eight (57%) showed complete remission, four (29%) partial remission, and two (14%) disease progression. ECT was well tolerated and the observed adverse effects were mostly mild and transient. The results suggest that ECT is an effective treatment of SCC in cats, especially cutaneous SCC in early stages or with lesions smaller than 3 cm in diameter.
ABSTRACT - ELECTROCHEMOTHERAPY FOR THE TREATMENT OF SQUAMOUS CELL CARCINOMA IN CATS: RETROSPECTIVE STUDY - Squamous cell carcinoma (SCC) is one of the most common malignant tumours in cats, representing approximately 15% of its cutaneous tumours and 60-75% of oral tumours. Electrochemotherapy (ECT) is a recent cancer treatment modality that combines the administration of chemotherapeutic agents, non-permeable or with low permeability, with the localized application of permeabilizing electric pulses. Short high-voltage pulses result in a substantial and transient increased permeability of neoplastic cells (electroporation) and the cytotoxicity of the chemotherapeutic agent increases by several orders of magnitude. Recently, ECT has been gaining popularity in Veterinary Oncology due to its high effectiveness associated with low toxicity. This retrospective study aimed to evaluate the efficacy of ECT with bleomycin as a treatment for cutaneous and oral SCC in cats. Fifteen cats with SCC of the head region (13 cutaneous SCC and 2 oral SCC) were treated with at least one ECT session at Hospital Veterinário Berna, between December 2015 and November 2016. Response to treatment was assessed four weeks after completion of treatment based on the Solid Neoplasm Response Assessment Criteria (RECIST) and adverse effects were graded according to the VCOG-CTCAE 2011. The overall response rate was 86%. Of the fourteen cats in which it was possible to classify the response, eight (57%) showed complete remission, four (29%) partial remission, and two (14%) disease progression. ECT was well tolerated and the observed adverse effects were mostly mild and transient. The results suggest that ECT is an effective treatment of SCC in cats, especially cutaneous SCC in early stages or with lesions smaller than 3 cm in diameter.
Description
Dissertação de Mestrado Integrado em Medicina Veterinária
Keywords
Electroporação quimioterapia carcinoma gato Electroporation chemotherapy carcinoma cats
Pedagogical Context
Citation
Sousa LPG. 2021. Eletroquimioterapia como tratamento de carcinoma de células escamosas em gatos : estudo retrospetivo [dissertação de mestrado]. Lisboa: FMV-Universidade de Lisboa.
Publisher
Universidade de Lisboa, Faculdade de Medicina Veterinária