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Authors
Advisor(s)
Abstract(s)
O mastocitoma cutâneo é um dos tumores malignos mais frequentes em canídeos. Apresenta um comportamento biológico complexo e a sua etiologia não é totalmente compreendida. O objetivo deste estudo foi investigar se a presença de doença dermatológica prévia influencia o prognóstico de doentes com mastocitoma, estudando a sua possível correlação com o grau histológico, a metastização e a sobrevida. A análise envolveu 33 cães com diagnóstico definitivo de mastocitoma cutâneo por análise histopatológica. A amostra foi dividida em 2 grupos de comparação: canídeos com história clínica dermatológica (n=16) e sem história clínica dermatológica (n=17). Foi ainda avaliada a perspetiva dos tutores dos doentes em estudo quanto a sinais sugestivos de dermatite atópica, tais como prurido e eritema, através da realização de um inquérito, com vista à identificação de um eventual subgrupo com doença dermatológica por diagnosticar. Com recurso ao teste exato de Fisher, foi avaliada a associação entre a história clínica dermatológica e a idade ao diagnóstico de mastocitoma (p=0,362) e o grau de Kiupel (p=0,699). Não foi demonstrada uma associação estatisticamente significativa entre a história dermatológica pregressa e o grau histológico do mastocitoma (p>0,05). A análise da associação entre os resultados do inquérito e o grau de Kiupel também não apresentou resultados estatisticamente significativos (p>0,05)
ABSTRACT - Retrospective Study on the Role of Skin Conditions as a Prognostic Factor in Patients with Mast Cell Tumours - Cutaneous mast cell tumour is one of the most common malignant tumours in dogs. It has a complex biological behaviour and its aetiology is not fully understood. The aim of this study was to investigate if the presence of previous skin conditions influences the prognosis of patients with canine mast cell tumours, studying its possible correlation with histological grade, metastization and survival. The study involved 33 dogs with a definitive diagnosis of cutaneous mast cell tumour diagnosis by histopathological analysis. The sample was divided into 2 comparison groups: dogs with dermatological medical history (n=16) and without dermatological medical history (n=17). The perspective of the owners of the patients under study regarding signs suggestive of atopic dermatitis, such as pruritus and erythema, was also assessed by means of a survey, with the aim of identifying a possible subgroup with undiagnosed dermatological disease. Fisher's exact test was used to assess the association between dermatological medical history and age at diagnosis of mast cell tumour (p=0.362) and Kiupel grade (p=0.699). There was no statistically significant association between past dermatological history and the histological grade of mast cell tumour (p>0.05). The analysis of the association between the results of the survey and the Kiupel grade also showed no statistically significant results (p>0.05)
ABSTRACT - Retrospective Study on the Role of Skin Conditions as a Prognostic Factor in Patients with Mast Cell Tumours - Cutaneous mast cell tumour is one of the most common malignant tumours in dogs. It has a complex biological behaviour and its aetiology is not fully understood. The aim of this study was to investigate if the presence of previous skin conditions influences the prognosis of patients with canine mast cell tumours, studying its possible correlation with histological grade, metastization and survival. The study involved 33 dogs with a definitive diagnosis of cutaneous mast cell tumour diagnosis by histopathological analysis. The sample was divided into 2 comparison groups: dogs with dermatological medical history (n=16) and without dermatological medical history (n=17). The perspective of the owners of the patients under study regarding signs suggestive of atopic dermatitis, such as pruritus and erythema, was also assessed by means of a survey, with the aim of identifying a possible subgroup with undiagnosed dermatological disease. Fisher's exact test was used to assess the association between dermatological medical history and age at diagnosis of mast cell tumour (p=0.362) and Kiupel grade (p=0.699). There was no statistically significant association between past dermatological history and the histological grade of mast cell tumour (p>0.05). The analysis of the association between the results of the survey and the Kiupel grade also showed no statistically significant results (p>0.05)
Description
Dissertação de Mestrado Integrado em Medicina Veterinária, área científica de Clínica
Keywords
Mastocitoma Inflamação cutânea Prognóstico Barreira cutânea Canídeo Mast cell tumour Skin inflammation Prognosis Skin barrier Canine
Pedagogical Context
Citation
Félix EMS. 2025. Estudo retrospetivo sobre o papel da patologia cutânea como fator de prognóstico em doentes com mastocitoma [dissertação de mestrado]. Lisboa: FMV-Universidade de Lisboa
Publisher
Universidade de Lisboa, Faculdade de Medicina Veterinária