A carregar...
Projeto de investigação
Effects of Combined vs. Resistance Training on Quality of Life and other Cancer-Related Biomarkers: a 4-month Randomized Control Trial conducted on Breast Cancer Patients Undergoing Chemotherapy
Financiador
Autores
Publicações
Sensor based sleep patterns and reported sleep quality in breast cancer patients undergoing neoadjuvant chemotherapy
Publication . Malveiro, Carla; Boavida, Sofia; Cargaleiro, Catarina; Bernardino, Ana Vilelas; Correia, Inês; Reis, Cátia; Matos, Leonor; Sardinha, Luís B.; Cardoso, Maria João; Saint-Maurice, Pedro F.
Breast cancer is the most diagnosed cancer in women worldwide and its treatment often leads to the onset of sleep disturbances. While much research has focused on chemotherapy's impact on overall sleep quality through subjective measures, less attention has been given to its effects on specific sleep metrics such as duration, timing, continuity, and naps. This preliminary study addresses this gap by assessing sleep duration, timing, and regularity, using the Emfit QS device over 100 consecutive days in 24 breast cancer patients undergoing neoadjuvant chemotherapy. Additionally, we incorporated the Pittsburgh Sleep Quality Index (PSQI) to measure reported sleep quality. Our results suggest that chemotherapy may influence the duration for time spent in bed (ptrend = 0.02) measured by the Emfit QS. Duration in bed decreased over the first seven weeks (e.g., 9.3 h/day at week 1 vs. 8.5 h/day at week 8), and increased thereafter to similar amounts as those recorded in week 1 (9.0 h/day at week 15). Sleep timing and regularity, also measured by the Emfit QS, remained unchanged. Overall sleep quality, as measured by the PSQI, did not change over time. However, our analysis of the individual components of the PSQI revealed that sleep disturbances increased as treatment progressed from week 1 to week 8 (1.3 ± 0.6 to 1.7 ± 0.6; p = 0.01), concurrently with an increase in insomnia symptoms. Approximately, 33%, 63%, and 73% reported having insomnia symptoms at week 1, 8, and 15. These findings highlight critical periods during treatment when patients are vulnerable to disrupted sleep. Future research should focus on interventions to mitigate sleep disturbances, improving patient well-being and overall quality of life.
Effect of exercise on immune system markers in cancer patients and survivors : a systematic review
Publication . Oliveira, Estela Carolina Calvo; Sardinha, Luís Fernando Cordeiro Bettencourt
Purpose: To present a systematic review on randomized controlled trials that analyzed the impact of aerobic, resistance, combined, and Tai Chi exercise on the immune system in cancer patients and survivors.
Methods: Pubmed, Web of Science, the Cochrane Library, and Scopus databases were searched to identify pertinent RCTs. Randomized controlled investigations that looked at the effect of exercise interventions with immune system markers as one of the outcomes were included. The methodological scale to evaluate the included investigations was the PEDro scale (Physiotherapy Evidence Database).
Results: Eleven articles met all the inclusion criteria. PEDro scale score ranged between 5 and 10 points, with an overall average of 6.9 points, with 2 investigations of excellent quality, 7 of good quality, and 2 of low quality. Of the 11 investigations, 3 observed beneficial results on the effect of aerobic, resistance, combined, and Tai Chi exercise on immune cells (NK cells) in cancer patients and survivors, and 8 reported no effects.
Conclusion: Few investigations suggest a between-group effect of exercise on the immune system in cancer patients and survivors when compared to a control group. More high-quality studies are needed in different phases and stages of treatment and disease and in different types, intensities, and durations of physical exercise.
Impact of combined training with different exercise intensities on inflammatory and lipid markers in type 2 diabetes : a secondary analysis from a 1-year randomized controlled trial
Publication . Magalhães, João P.; Santos, Diana A.; Correia, Inês; Hetherington-Rauth, Megan; Ribeiro, Rogério; Raposo, João F.; Matos, Andreia; Bicho, Manuel; Sardinha, Luís B.
Background: Exercise is a well-accepted strategy to improve lipid and infammatory profle in individuals with type 2 diabetes (T2DM). However, the exercise intensity having the most benefts on lipids and infammatory markers in patients with T2DM remains unclear. We aimed to analyse the impact of a 1-year combined high-intensity interval training (HIIT) with resistance training (RT), and a moderate continuous training (MCT) with RT on infammatory and lipid profle in individuals with T2DM. Methods: Individuals with T2DM (n=80, aged 59 years) performed a 1-year randomized controlled trial and were randomized into three groups (control, n=27; HIIT with RT, n=25; MCT with RT, n=28). Exercise sessions were super‑ vised with a frequency of 3 days per week. Infammatory and lipid profles were measured at baseline and at 1-year follow-up. Changes in infammatory and lipid markers were assessed using generalized estimating equations. Results: After adjusting for sex, age and baseline moderate-to-vigorous physical activity (MVPA), we observed a time-by-group interaction for Interleukin-6 (IL-6) in both the MCT with RT (β=−0.70, p=0.034) and HIIT with RT (β=−0.62, p=0.049) groups, whereas, only the HIIT with RT group improved total cholesterol (β=−0.03, p=0.045) and LDL-C (β=−0.03, p=0.034), when compared to control. No efect was observed for C-reactive protein (CRP), cortisol, tumour necrosis factor-α (TNF-α), soluble form of the haptoglobin-hemoglobin receptor CD163 (sCD163), triglycerides and HDL-C in both groups (p>0.05). Conclusions: Favorable adaptations on IL-6 were observed in both the HIIT and MCT combined with RT groups fol‑ lowing a long-term 1-year exercise intervention in individuals with T2DM. However, only the HIIT with RT prevented further derangement of total cholesterol and LDL-C, when compared to the control group. Therefore, in order to encourage exercise participation and improve infammatory profle, either exercise protocols may be prescribed, however, HIIT with RT may have further benefts on the lipid profle.
Unidades organizacionais
Descrição
Palavras-chave
Contribuidores
Financiadores
Entidade financiadora
Fundação para a Ciência e a Tecnologia
Programa de financiamento
Número da atribuição
SFRH/BD/149394/2019