Browsing by Author "Lopes, Cristina"
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- Optimizing the use of systemic corticosteroids in severe asthma (ROSA II project): a national Delphi consensus studyPublication . Marques, João; Duarte-Ramos, Filipa; Ferreira, Manuel Branco; Lima, Ricardo; Lopes, Cristina; Sokolova, Anna; Tonin, Fernanda Stumpf; Loureiro, Cláudia ChavesAlthough the prevalence of severe asthma is not high (5-10% of patients), it is responsible for a large part of the overall disease burden and costs (50-60% of total costs), especially if the condition remains uncontrolled (which occurs in around 40% of cases). Currently, for patients without disease control or presenting frequent exacerbations despite optimal therapy, add-on treatments, traditionally long-acting anticholinergics, oral corticosteroids (OCS) or biologic agents (monoclonal antibodies) are recommended.2 Nonetheless, the long-term use of oral/systemic corticosteroids (CS) is significantly associated with adverse effects, acute and chronic complications that may decrease health-related quality of life and worsen prognosis, thus requiring additional monitoring and management. Conversely, target therapies (i.e., omalizumab, mepolizumab, reslizumab, benralizumab and more recently, dupilumab) have been developed grounded on the different phenotypes and endotypes of severe asthma, and are gradually reducing the reliance on OCS (i.e., greater specificity for achieving disease control by reducing the risk of exacerbations and requirements for rescue medication and OCS, with limited adverse events).
- Sete anos de experiência, sete lições para o futuro: formando utilizadores em literacia de informaçãoPublication . Sanches, Tatiana; Revez, Jorge; Lopes, CristinaO presente estudo faz o balanço da implementação e do desenvolvimento de uma estratégia de formação em literacia de informação, realizada na Biblioteca da Faculdade de Psicologia e do Instituto de Educação da Universidade de Lisboa. Para captar essa experiência foram tidos em conta os quadros teóricos que englobam a literacia da informação e a formação de utilizadores. Metodologicamente optou-se pelo estudo de caso, baseado na análise da documentação interna produzida, incluindo estatísticas de utilização dos recursos de informação, e no tratamento longitudinal dos dados provenientes dos inquéritos aplicados aos utilizadores. Os sete anos decorridos desde o início do processo (2008-2014) foram marcados pela adaptação sistemática da estratégia à mudança contextual. O estudo conclui que os sete aspetos principais que se podem destacar desta análise podem ser compreendidos prospectivamente como sete lições para o futuro que podem apoiar a capacitação das bibliotecas universitárias portuguesas na ligação, transformação e criação de valor através da função pedagógica que desempenham no ensino superior.
- The portuguese severe asthma registry : development, features, and data sharing policiesPublication . Sousa, Ana Sá; Fonseca, João Almeida; Pereira, Ana Margarida; Ferreira, Ana; Arrobas, Ana; Mendes, Ana; Drummond, Marta; Videira, Wanda; Costa, Tiago; Farinha, Pedro; Soares, José; Rocha, Pedro; Todo-Bom, Ana; Sokolova, Anna; Costa, António; Fernandes, Beatriz; Loureiro, Carla Chaves; Longo, Cecília; Pardal, Cecília; Costa, Célia; Cruz, Cíntia; Loureiro, Cláudia Chaves; Lopes, Cristina; Mesquita, Duarte; Faria, Emília; Magalhães, Eunice; Menezes, Fernando; Todo-Bom, Filipa; Carvalho, Francisca; Regateiro, Frederico S.; Falcão, Helena; Fernandes, Ivone; Marques, João Gaspar; Viana, Jorge; Ferreira, José; Silva, José Manuel; Simão, Laura; Almeida, Leonor; Fernandes, Lígia; Ferreira, Lurdes; van Zeller, Mafalda; Quaresma, Márcia; Castanho, Margarida; André, Natália; Cortesão, Nuno; Pinto, Paula Leiria; Pinto, Paula; Rosa, Paula; Martins, Pedro Carreiro; Gerardo, Rita; Silva, Rui; Lucas, Susana; Almeida, Teresa; Calvo, TeresaThe Portuguese Severe Asthma Registry (Registo de Asma Grave Portugal, RAG) was developed by an open collaborative network of asthma specialists. RAG collects data from adults and pediatric severe asthma patients that despite treatment optimization and adequate management of comorbidities require step 4/5 treatment according to GINA recommendations. In this paper, we describe the development and implementation of RAG, its features, and data sharing policies. The contents and structure of RAG were defined in a multistep consensus process. A pilot version was pretested and iteratively improved. The selection of data elements for RAG considered other severe asthma registries, aiming at characterizing the patient's clinical status whilst avoiding overloading the standard workflow of the clinical appointment. Features of RAG include automatic assessment of eligibility, easy data input, and exportable data in natural language that can be pasted directly in patients' electronic health record and security features to enable data sharing (among researchers and with other international databases) without compromising patients' confidentiality. RAG is a national web-based disease registry of severe asthma patients, available at asmagrave.pt. It allows prospective clinical data collection, promotes standardized care and collaborative clinical research, and may contribute to inform evidence-based healthcare policies for severe asthma.