Browsing by Author "Fernandes, Isabel"
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- c-Met expression in renal cell carcinoma with bone metastasesPublication . Silva Paiva, Rita; Fernandes Gomes, Inês; Casimiro, Sandra; Fernandes, Isabel; Costa, LuisHepatocyte growth factor (HGF)/c-Met pathway is implicated in embryogenesis and organ development and differentiation. Germline or somatic mutations, chromosomal rearrangements, gene amplification, and transcriptional upregulation in MET or alterations in autocrine or paracrine c-Met signalling have been associated with cancer cell proliferation and survival, including in renal cell carcinoma (RCC), and associated with disease progression. HGF/c-Met pathway has been shown to be particularly relevant in tumors with bone metastases (BMs). However, the efficacy of targeting c-Met in bone metastatic disease, including in RCC, has not been proven. Therefore, further investigation is required focusing the particular role of HGF/c-Met pathway in bone microenvironment (BME) and how to effectively target this pathway in the context of bone metastatic disease.
- A case of success: complete response to Radium-223 in metastatic castration-resistant prostate cancerPublication . Soares De Pinho, Inês; Esperança Martins, Miguel; Machado, Bárbara; Dâmaso, Sara; Brás, Raquel; Cantinho, Guilhermina; Fernandes, Isabel; Costa, LuisRadium-223 dichloride (Ra223) is the first targeted alpha agent approved for treating metastatic castration-resistant prostate cancer (mCRPC) with bone-exclusive disease. A benefit in overall survival and time to the first symptomatic skeletal-related event was shown in the Alpharadin in Symptomatic Prostate Cancer Patients (ALSYMPCA) trial. However, this trial did not describe a bone scan response to Ra223, and there is no universal consensus about how it should be monitored. Furthermore, a scintigraphy flare phenomenon may lead to false-positive tracer uptake in responsive cases, thereby misleading the interpretation of imaging results. We present the case of a 67-year-old male with mCRPC and exclusive bone disease treated with Ra223. The bone scintigraphy after the end of the treatment showed an apparent aggravation of the lesions, corresponding to a flare phenomenon, with an almost complete resolution after three months. The patient maintained a scintigraphic response for seven months.
- Castration-resistant prostate cancer: mechanisms, targets, and treatmentPublication . Amaral, Teresa; Macedo, Daniela; Fernandes, Isabel; Costa, LuisPatients with castration-resistant prostate cancer (CRPC), who progress after docetaxel therapy, had until very recently, only a few therapeutic options. Recent advances in this field brought about new perspectives in the treatment of this disease. Molecular, basic, and translational research has given us a better understanding on the mechanisms of CRPC. This great investment has turned into a more rational approach to the development of new drugs. Some of the new treatments are already available to our patients outside clinical trials and may include inhibitors of androgen biosynthesis; new chemotherapy agents; bone-targeted therapy; and immunotherapy. This paper aims to review the mechanisms of prostate cancer resistance, possible therapeutic targets, as well as new options to treat CRPC.
- Conservação in situ e ex situ no Parque Botânico da Tapada da AjudaPublication . Vasconcelos, Teresa; Forte, Paulo; Fernandes, Isabel
- Contar (com) a MedicinaPublication . Fernandes, Isabel; Cabral, Maria de Jesus; Casal, Teresa; Correia, Alda; Almeida, DianaContar (com) a Medicina reúne um conjunto de sessenta excertos, maioritariamente ficcionais, traduzidos do Alemão, Francês e Inglês, mas também do Castelhano e Sueco, incidindo sobre autores do século XX, e relacionados com a medicina. Os textos são precedidos por uma nota introdutória que oferece o respetivo enquadramento. A antologia organiza-se em três secções intituladas "Doentes", "Cuidadores" e "Família", de acordo com a perspetiva de quem vive, e de quem descreve ou de quem reflete sobre a doença e a saúde, a perceção do corpo, a palavra e o silêncio, a relação médico/doente, o saber científico e o contato humano, na interface da técnica com a ética. Os temas aqui abordados são tão variados quanta a diversidade de autores e textos reunidos.
- Contar (com) a MedicinaPublication . Cabral, Maria de Jesus; Fernandes, Isabel; Casal, Teresa; Correia, Alda; Almeida, DianaContar (com) a medicina reúne um conjunto excertos, maioritariamente ficcionais, traduzidos do alemão, francês e inglês, mas também do castelhano e do sueco, incidindo maioritariamente sobre autores do século XX, e relacionados com a medicina. Os textos são precedidos por uma nota introdutória que oferece um enquadramento do texto, bem como por palavras-chave. A antologia organiza-se em três secções intituladas Doentes, Cuidadores e Família, de acordo com a perspetiva de quem vive, e de quem descreve ou de quem reflete sobre a doença e a saúde, a perceção do corpo, a palavra e o silêncio, a relação médico/doente, o saber científico e o contato humano, na interface da técnica com a ética.
- Cozinhar e comer no Castelo Medieval de PalmelaPublication . Fernandes, Isabel; Cardoso, João Luís; Detry, Cleia
- Did the Romans introduce the Egyptian mongoose (Herpestes ichneumon) into the Iberian Peninsula?Publication . Detry, Cleia; Cardoso, João Luís; Heras Mora, Javier; Bustamante-Álvarez, Macarena; Silva, Ana Maria; Pimenta, João; Fernandes, Isabel; Fernandes, CarlosNew finds of bones of the Egyptian Mongoose (Herpestes ichneumon), one from Portugal and one from Spain, were directly 14C dated to the first century AD. While the Portuguese specimen was found without connection to the Chalcolithic occupation of the Pedra Furada cave where it was recovered, the Spanish find, collected in the city of Mérida, comes from a ritual pit that also contained three human and 40 dog burials. The finds reported here show that the Egyptian mongoose, contrary to the traditional and predominant view, did not first arrive in the Iberian Peninsula during the Muslim occupation of Iberia. Instead, our findings are consistent with the hypothesis that the species was first introduced by the Romans, or at least sometime during the Roman occupation of Hispania. Therefore, radiocarbon dating of new archaeological finds of bones of the Egyptian Mongoose (Herpestes ichneumon) in the Iberian Peninsula push back the confirmed presence of the species in the region by approximately eight centuries, as the previously oldest dated record is from the ninth century. With these new dates, there are now a total of four 14C dated specimens of Egyptian mongooses from the Iberian Peninsula, and all of these dates fall within the last 2000 years. This offers support for the hypothesis that the presence of the species in Iberia is due to historical introductions and is at odds with a scenario of natural sweepstake dispersal across the Straits of Gibraltar in the Late Pleistocene (126,000-11,700 years ago), recently proposed based on genetic data.
- Du plaisir du texte à l’utilité de la littératurePublication . Fernandes, IsabelDans mon article je propose de revenir à Barthes et de reprendre en particulier Le Plaisir du Texte (1973), qui marque un tournant épistémologique dans l’œuvre vers le poststructuralisme. Barthes y souligne l’importance de la matière signifiante et la dérive qu’elle permet ; il insiste aussi sur la position antisystème envers l’académie et la critique institutionnelle. Je rapproche les analyses barthésiennes de certaines prises de positions récentes dans le monde anglophone, notamment celles de M. H. Abrams (2012) et de Rita Felski (2008). Ces auteurs attirent à leur façon l’attention sur le(s) pouvoir(s) du texte littéraire et sa lecture. Je termine par quelques mots sur le projet en Médecine Narrative, que je placerai également sous l’égide barthésienne.
- Os Estudos Literários no séc. XXI : o passado próximo, a crise e o próximo futuroPublication . Fernandes, IsabelTomando como ponto de partida as obras How to Read a Poem (2006) de Terry Eagleton, e La littérature en péril (2007) de Tzvetan Todorov, pretende-se discorrer, neste capítulo, sobre o ensino da literatura, em especial no ensino superior.