c-Met expression in renal cell carcinoma with bone metastases

Silva Paiva, Rita; Fernandes Gomes, Inês; Casimiro, Sandra; Fernandes, Isabel; Costa, Luis

http://hdl.handle.net/10451/49082

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Authors

Silva Paiva, Rita

Fernandes Gomes, Inês

Casimiro, Sandra

Fernandes, Isabel

Costa, Luis

Abstract(s)

Hepatocyte growth factor (HGF)/c-Met pathway is implicated in embryogenesis and organ development and differentiation. Germline or somatic mutations, chromosomal rearrangements, gene amplification, and transcriptional upregulation in MET or alterations in autocrine or paracrine c-Met signalling have been associated with cancer cell proliferation and survival, including in renal cell carcinoma (RCC), and associated with disease progression. HGF/c-Met pathway has been shown to be particularly relevant in tumors with bone metastases (BMs). However, the efficacy of targeting c-Met in bone metastatic disease, including in RCC, has not been proven. Therefore, further investigation is required focusing the particular role of HGF/c-Met pathway in bone microenvironment (BME) and how to effectively target this pathway in the context of bone metastatic disease.