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c-Met expression in renal cell carcinoma with bone metastases

2020Journal article Open access
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dc.contributor.authorSilva Paiva, Rita
dc.contributor.authorFernandes Gomes, Inês
dc.contributor.authorCasimiro, Sandra
dc.contributor.authorFernandes, Isabel
dc.contributor.authorCosta, Luis
dc.date.accessioned2021-07-23T12:28:38Z
dc.date.available2021-07-23T12:28:38Z
dc.date.issued2020
dc.description© 2020 The Author(s). Published by Elsevier GmbH. This is an open access article under the CC BY-NC-ND license. (http://creativecommons.org/licenses/BY-NC-ND/4.0/)pt_PT
dc.description.abstractHepatocyte growth factor (HGF)/c-Met pathway is implicated in embryogenesis and organ development and differentiation. Germline or somatic mutations, chromosomal rearrangements, gene amplification, and transcriptional upregulation in MET or alterations in autocrine or paracrine c-Met signalling have been associated with cancer cell proliferation and survival, including in renal cell carcinoma (RCC), and associated with disease progression. HGF/c-Met pathway has been shown to be particularly relevant in tumors with bone metastases (BMs). However, the efficacy of targeting c-Met in bone metastatic disease, including in RCC, has not been proven. Therefore, further investigation is required focusing the particular role of HGF/c-Met pathway in bone microenvironment (BME) and how to effectively target this pathway in the context of bone metastatic disease.pt_PT
dc.description.sponsorshipIG is supported by the Fundação para a Ciência e Tecnologia (FCT) PhD grant SFRH/BD/139178/2018.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationJ Bone Oncol. 2020 Sep 16;25:100315.pt_PT
dc.identifier.doi10.1016/j.jbo.2020.100315pt_PT
dc.identifier.eissn2212-1374
dc.identifier.issn2212-1366
dc.identifier.urihttp://hdl.handle.net/10451/49082
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationRANK-pathway as a mediator of resistance to cyclin inhibitors and HER2-targeted therapies in breast cancer
dc.relation.publisherversionhttps://www.sciencedirect.com/journal/journal-of-bone-oncologypt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectBone metastasespt_PT
dc.subjectKidney cancerpt_PT
dc.subjectHGF/c-Metpt_PT
dc.subjectTargeted therapypt_PT
dc.titlec-Met expression in renal cell carcinoma with bone metastasespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleRANK-pathway as a mediator of resistance to cyclin inhibitors and HER2-targeted therapies in breast cancer
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F139178%2F2018/PT
oaire.citation.titleJournal of Bone Oncologypt_PT
oaire.citation.volume25pt_PT
person.familyNameFernandes Gomes
person.familyNameCara de Anjo Casimiro
person.familyNameFernandes
person.familyNameCosta
person.givenNameInês
person.givenNameSandra Cristina
person.givenNameIsabel
person.givenNameLuis
person.identifier.ciencia-id4114-34EA-AD95
person.identifier.ciencia-id0F12-5181-0B22
person.identifier.ciencia-idD811-E1C9-9209
person.identifier.ciencia-id041E-4ADE-FB64
person.identifier.orcid0000-0003-0985-0821
person.identifier.orcid0000-0002-6917-4477
person.identifier.orcid0000-0003-4032-7713
person.identifier.orcid0000-0002-4782-7318
person.identifier.scopus-author-id14043403400
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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