Browsing by Author "Costa, Ana"
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- Alfabetização Baseada na Ciência: Manual do Curso ABCPublication . Costa, Ana; Silva, Ana Cristina; Soares, Ana Paula; Vale, Ana Paula; Aguiar, Cecília; Alves, Diana; Gomes, Inês; Cadime, Irene; Alçada, Isabel; Leite, Isabel; Lopes, João A.; Veloso, João; Moats, Louisa C.; Mata, Lurdes; Joshi, Malatesha; Martins, Margarida Alves; Ramalho, Margarida; Silva, Mariana; Lousada, Marisa; Martins, Marta; Moura, Octávio; Sousa, Otília; Treiman, Rebecca; Alves, Rui A.; Fernandes, Sandra; Araújo, Susana; Carreker, Suzanne; Costa Pereira, Teresa; Goucha, Tomás
- Efeitos de modelização no input: o caso da aquisição de conectoresPublication . Costa, Ana; Alexandre, Nélia; Santos, Ana Lúcia; Soares, NunoNeste trabalho, discutimos algumas hipóteses sobre o papel do input na aquisição, em particular sobre os efeitos, na aquisição, da frequência no input. Levantaremos um problema metodológico aos trabalhos que usam a frequência no input como hipótese explicativa da ordenação dos estádios na aquisição: ao contrário do que é comummente assumido, o input não é estável, verificando-se efeitos de adaptação do discurso ao estádio em que a criança se encontra.
- Ensino da leitura e da escrita baseado em evidênciasPublication . Costa, Ana; Silva, Ana Cristina; Soares, Ana Paula; Vale, Ana Paula; Aguiar, Cecília; Alves, Diana; Gomes, Inês; Cadime, Irene; Alçada, Isabel; Leite, Isabel; Lopes, João A.; Veloso, João; Moats, Louisa; Mata, Lourdes; Joshi, Malatesha; Martins, Margarida Alves; Ramalho, Margarida; Silva, Mariana; Lousada, Marisa; Martins, Marta; Moura, Octávio; Sousa, Otília; Treiman, Rebecca; Alves, Rui A.; Fernandes, Sandra; Araújo, Susana; Carreker, Suzanne; Costa Pereira, Teresa; Goucha, TomásO que é que as ciências sabem sobre o ensino e a aprendizagem da leitura e da escrita em português? Esta foi a pergunta que os editores do manual Ensino da Leitura e da Escrita Baseado em Evidências colocaram a mais de 30 especialistas investigadores. Esta publicação sintetiza as noções fundamentais sobre a alfabetização que um professor alfabetizador moderno deve conhecer; foca a literacia emergente, isto é, aquilo que as crianças podem descobrir sobre a escrita e a leitura antes de chegarem à escola; e discute as dificuldades e as perturbações na aprendizagem da leitura e da escrita. Este manual é, por isso, uma fonte importante de atualização científica para os professores que ensinam a ler e a escrever, os professores do 1º ciclo, e para quem prepara essa aprendizagem, os educadores de infância. É também apropriado para estudantes do Ensino Superior, futuros professores, porque os coloca em contacto com um conjunto de descobertas científicas e conhecimento importantes para uma prática pedagógica fundamentada, destaca a relevância do conhecimento empírico e da sua permanente atualização e, através das sugestões pedagógicas e propostas de atividades, faz a ponte para o dia a dia na sala de aula.
- Exploring the multifaceted potential of a peptide fraction derived from Saccharomyces cerevisiae metabolism: antimicrobial, antioxidant, antidiabetic, and anti-inflammatory propertiesPublication . Branco, Patrícia; Maurício, Elisabete Muchagato; Costa, Ana; Ventura, Diogo; Roma-Rodrigues, Catarina; Duarte, Maria Paula; Fernandes, Alexandra R.; Prista, CatarinaThe rising demand for minimally processed, natural, and healthier food products has led to the search for alternative and multifunctional bioactive food components. Therefore, the present study focuses on the functional proprieties of a peptide fraction derived from Saccharomyces cerevisiae metabolism. The antimicrobial activity of the peptide fraction is evaluated against various foodborne pathogens, including Candida albicans, Candida krusei, Escherichia coli, Listeria monocytogenes, and Salmonella sp. The peptide fraction antioxidant properties are assessed using FRAP and DPPH scavenging capacity assays. Furthermore, the peptide fraction’s cytotoxicity is evaluated in colorectal carcinoma and normal colon epithelial cells while its potential as an antidiabetic agent is investigated through -amylase and -glucosidase inhibitory assays. The results demonstrate that the 2–10 kDa peptide fraction exhibits antimicrobial effects against all tested microorganisms, except C. krusei. The minimal inhibitory concentration for E. coli, L. monocytogenes, and Salmonella sp. remains consistently low, at 0.25 mg/mL, while C. albicans requires a higher concentration of 1.0 mg/mL. Furthermore, the peptide fraction displays antioxidant activity, as evidenced by DPPH radical scavenging activity of 81.03%, and FRAP values of 1042.50 32.5 M TE/mL at 1.0 mg/mL. The peptide fraction exhibits no cytotoxicity in both tumor and non-tumoral human cells at a concentration up to 0.3 mg/mL. Moreover, the peptide fraction presents anti-inflammatory activity, significantly reducing the expression of the TNF gene by more than 29.7% in non-stimulated colon cells and by 50% in lipopolysaccharide-stimulated colon cells. It also inhibits the activity of the carbohydrate digestive enzymes -amylase (IC50 of 199.3 0.9 g/mL) and -glucosidase (IC20 of 270.6 6.0 g/mL). Overall, the findings showed that the peptide fraction exhibits antibacterial, antioxidant, anti-inflammatory, and antidiabetic activity. This study represents a step forward in the evaluation of the functional biological properties of S. cerevisiae bioactive peptides.
- Pelvic floor muscle function after grade II tears: surface electromyography test–retest and differences between nulliparous and primiparousPublication . Mota, Patrícia; Costa, Ana; Santos, Diana; Santo, Susana; Barros, Joana; Bø, KariBackground: Vaginal birth is a risk factor for weakening of the pelvic floor muscles (PFM) and development of pelvic floor dysfunction (PFD). Perineal tears may decrease PFM function. PFM tone can be assessed with surface EMG (sEMG), but reliability studies of sEMG in women with perineal tears are lacking. The aims of this study were to evaluate test-retest and intrarater reliability of sEMG and compare PFM activation between nulliparous and primiparous. Methods: A sEMG test-retest was performed in 21 women (12 nulliparous and 9 primiparous with grade II tears) to assess intra-rater reliability during rest and maximal voluntary contraction (MVC) of the PFM. Intraclass Correlation Coefficient (ICC), standard error of measurement (SEM) and minimal detectable change (MDC) were tested. A comparison between nulliparous' and primiparous' PFM activation during rest and MVC was performed. Results: sEMG demonstrated fair reliability in nulliparous (ICC: 0.239; SEM: 5.2; MDC: 14.5) and moderate reliability in primiparous (ICC: 0.409; SEM: 1.5; MDC: 4.2) during rest. For peak MVC very good intrarater reliability was found in nulliparous (ICC: 0.92; SEM: 8.0; MDC: 22.2) and in primiparous (ICC: 0.823; SEM: 8.0; MDC: 22.2). Statistically significant lower PFM activation was found in primiparous women with perineal tear grade II than in nulliparous at rest (mean difference 9.1 µV, 95% confidence interval [CI] 3.0-19.0, p = 0.001), and during MVCpeak (mean difference 50.0 µV, 95% CI 10.0-120.0 p = 0.021). Conclusions: sEMG is reliable when measuring PFM activation in primiparous women with perineal tears grade II. Women with perineal tears grade II have lower PFM activation both during rest and MVC.
- Sustainable valorization of food-processing industry by-products: challenges and opportunities to obtain bioactive compoundsPublication . Simões, Sandra; Costa, Ana; Faria-Silva, Ana Catarina; Ascenso, Andreia; Marto, Joana; Carvalheiro, Manuela; Gonçalves, Lídia; Marques, M.; Paiva, A.; Bento, M.; Simões, P.; Ribeiro, HelenaThe food-processing industry generates large quantities of residues, which may represent sustainable and rich sources of bioactive compounds. The extraction of bioactives from industrial residues could be a good alternative for the valorization of this by-product with recognized biological actions. Conventional extraction methods consume large volumes of organic solvents, which are expensive, toxic, and hazardous. Traces of the extractants in the final product make it unsuitable for pharmaceutical or cosmetic uses. Several methods, considered “green” or “eco-friendly,” have been proposed because of the low contamination, nontoxic, and nonflammable characteristics of the techniques. This chapter reviews the use of bioactive-enriched extracts obtained by environmentally friendly processes with sufficient quality to be incorporated into nutraceutical, pharmaceutical, and cosmetic formulations, highlights the challenges regarding bioactive compounds’ chemical stability, and presents the more recent strategies to overcome the technological issues of extracted bioactive molecules. The new concepts for recovered bioactives application are discussed.