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http://hdl.handle.net/10451/60956| Título: | Altered plasma protein profiles in genetic FTD – a GENFI study |
| Autor: | Ullgren, Abbe Öijerstedt, Linn Olofsson, Jennie Bergström, Sofia Remnestål, Julia van Swieten, John C. Jiskoot, Lize C. Seelaar, Harro Borroni, Barbara Sanchez-Valle, Raquel Moreno, Fermin Peakman, Georgia Pievani, Michela Pijnenburg, Yolande Premi, Enrico Prioni, Sara Rademakers, Rosa Redaelli, Veronica Rinaldi, Daisy Rittman, Tim Rogaeva, Ekaterina Laforce, Robert Rollin, Adeline Rosa-Neto, Pedro Rossi, Giacomina Rosser, Martin Scarpini, Elio Semler, Elisa Shafei, Rachelle Shoesmith, Christen Tábuas-Pereira, Miguel Tainta, Mikel Synofzik, Matthis Taipa, Ricardo Tang-Wai, David Thomas, David L. Thompson, Paul Thonberg, Håkan Timberlake, Carolyn Todd, Emily Van Damme, Philip Vandenbulcke, Mathieu Veldsman, Michele Galimberti, Daniela Verdelho, Ana Villanua, Jorge Warren, Jason Wilke, Carlo Woollacott, Ione Zetterberg, Henrik Zulaica, Miren Durães, João Lima, Marisa Lemos, João Rowe, James B. Masellis, Mario Tartaglia, Maria Carmela Finger, Elizabeth Vandenberghe, Rik De Mendonça, Alexandre Tirabosch, Pietro Santana, Isabel Ducharme, Simon Butler, Chris R. Gerhard, Alexander Otto, Markus Bouzigues, Arabella Russell, Lucy Swift, Imogen J. Sogorb-Esteve, Aitana Heller, Carolin Rohrer, Jonathan D. Månberg, Anna Nilsson, Peter Graff, Caroline Afonso, Sónia Almeida, Maria Rosario Anderl-Straub, Sarah Andersson, Christin Antonell, Anna Arighi, Andrea Balasa, Mircea Barandiaran, Myriam Bargalló, Nuria Bartha, Robart Bender, Benjamin Buratti, Emanuele Benussi, Luisa Bertoux, Maxime Binetti, Giuliano Black, Sandra Bocchetta, Martina Borrego-Ecija, Sergi Bras, Jose Bruffaerts, Rose Cañada, Marta Cantoni, Valentina Caroppo, Paola Cash, David Castelo-Branco, Miguel Convery, Rhian Cope, Thomas Deramecourt, Vincent Di Fede, Giuseppe Díez, Alina Fenoglio, Chiara Ferreira, Catarina B. Fox, Nick Freedman, Morris Fumagalli, Giorgio Funkiewiez, Aurélie Gabilondo, Alazne Gasparotti, Roberto Gauthier, Serge Alberici, Antonella Giaccone, Giorgio Gorostidi, Ana Greaves, Caroline Guerreiro, Rita Indakoetxea, Begoña Jelic, Vesna Karnath, Hans-Otto Keren, Ron Kuchcinski, Gregory Langheinrich, Tobias Lebouvier, Thibaud Leitão, Maria João Lladó, Albert Maruta, Carolina Meeter, Lieke Miltenberger-Miltenyi, Gabriel van Minkelen, Rick Mitchell, Sara Moore, Katrina Nicholas, Jennifer Olives, Jaume Ourselin, Sebastien Padovani, Alessandro Panman, Jessica Papma, Janne M. |
| Palavras-chave: | C9orf72 Frontotemporal dementia GRN MAPT Neurodegeneration Plasma biomarkers |
| Data: | 2023 |
| Editora: | Springer Nature |
| Citação: | Mol Neurodegener. 2023 Nov 15;18(1):85 |
| Resumo: | Background: Plasma biomarkers reflecting the pathology of frontotemporal dementia would add significant value to clinical practice, to the design and implementation of treatment trials as well as our understanding of disease mechanisms. The aim of this study was to explore the levels of multiple plasma proteins in individuals from families with genetic frontotemporal dementia. Methods: Blood samples from 693 participants in the GENetic Frontotemporal Dementia Initiative study were analysed using a multiplexed antibody array targeting 158 proteins. Results: We found 13 elevated proteins in symptomatic mutation carriers, when comparing plasma levels from people diagnosed with genetic FTD to healthy non-mutation controls and 10 proteins that were elevated compared to presymptomatic mutation carriers. Conclusion: We identified plasma proteins with altered levels in symptomatic mutation carriers compared to non-carrier controls as well as to presymptomatic mutation carriers. Further investigations are needed to elucidate their potential as fluid biomarkers of the disease process. |
| Descrição: | © The Author(s) 2023. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
| Peer review: | yes |
| URI: | http://hdl.handle.net/10451/60956 |
| DOI: | 10.1186/s13024-023-00677-6 |
| Versão do Editor: | https://molecularneurodegeneration.biomedcentral.com/ |
| Aparece nas colecções: | FM - Artigos em Revistas Internacionais IMM - Artigos em Revistas Internacionais |
Ficheiros deste registo:
| Ficheiro | Descrição | Tamanho | Formato | |
|---|---|---|---|---|
| Plasma_protein.pdf | 1,09 MB | Adobe PDF | Ver/Abrir |
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