Logo do repositório
 
Publicação

Altered plasma protein profiles in genetic FTD – a GENFI study

2023Artigo científico Acesso aberto
Ver registo simples
dc.contributor.authorUllgren, Abbe
dc.contributor.authorÖijerstedt, Linn
dc.contributor.authorOlofsson, Jennie
dc.contributor.authorBergström, Sofia
dc.contributor.authorRemnestål, Julia
dc.contributor.authorvan Swieten, John C.
dc.contributor.authorJiskoot, Lize C.
dc.contributor.authorSeelaar, Harro
dc.contributor.authorBorroni, Barbara
dc.contributor.authorSanchez-Valle, Raquel
dc.contributor.authorMoreno, Fermin
dc.contributor.authorPeakman, Georgia
dc.contributor.authorPievani, Michela
dc.contributor.authorPijnenburg, Yolande
dc.contributor.authorPremi, Enrico
dc.contributor.authorPrioni, Sara
dc.contributor.authorRademakers, Rosa
dc.contributor.authorRedaelli, Veronica
dc.contributor.authorRinaldi, Daisy
dc.contributor.authorRittman, Tim
dc.contributor.authorRogaeva, Ekaterina
dc.contributor.authorLaforce, Robert
dc.contributor.authorRollin, Adeline
dc.contributor.authorRosa-Neto, Pedro
dc.contributor.authorRossi, Giacomina
dc.contributor.authorRosser, Martin
dc.contributor.authorScarpini, Elio
dc.contributor.authorSemler, Elisa
dc.contributor.authorShafei, Rachelle
dc.contributor.authorShoesmith, Christen
dc.contributor.authorTábuas-Pereira, Miguel
dc.contributor.authorTainta, Mikel
dc.contributor.authorSynofzik, Matthis
dc.contributor.authorTaipa, Ricardo
dc.contributor.authorTang-Wai, David
dc.contributor.authorThomas, David L.
dc.contributor.authorThompson, Paul
dc.contributor.authorThonberg, Håkan
dc.contributor.authorTimberlake, Carolyn
dc.contributor.authorTodd, Emily
dc.contributor.authorVan Damme, Philip
dc.contributor.authorVandenbulcke, Mathieu
dc.contributor.authorVeldsman, Michele
dc.contributor.authorGalimberti, Daniela
dc.contributor.authorVerdelho, Ana
dc.contributor.authorVillanua, Jorge
dc.contributor.authorWarren, Jason
dc.contributor.authorWilke, Carlo
dc.contributor.authorWoollacott, Ione
dc.contributor.authorZetterberg, Henrik
dc.contributor.authorZulaica, Miren
dc.contributor.authorDurães, João
dc.contributor.authorLima, Marisa
dc.contributor.authorLemos, João
dc.contributor.authorRowe, James B.
dc.contributor.authorMasellis, Mario
dc.contributor.authorTartaglia, Maria Carmela
dc.contributor.authorFinger, Elizabeth
dc.contributor.authorVandenberghe, Rik
dc.contributor.authorDe Mendonça, Alexandre
dc.contributor.authorTirabosch, Pietro
dc.contributor.authorSantana, Isabel
dc.contributor.authorDucharme, Simon
dc.contributor.authorButler, Chris R.
dc.contributor.authorGerhard, Alexander
dc.contributor.authorOtto, Markus
dc.contributor.authorBouzigues, Arabella
dc.contributor.authorRussell, Lucy
dc.contributor.authorSwift, Imogen J.
dc.contributor.authorSogorb-Esteve, Aitana
dc.contributor.authorHeller, Carolin
dc.contributor.authorRohrer, Jonathan D.
dc.contributor.authorMånberg, Anna
dc.contributor.authorNilsson, Peter
dc.contributor.authorGraff, Caroline
dc.contributor.authorAfonso, Sónia
dc.contributor.authorAlmeida, Maria Rosario
dc.contributor.authorAnderl-Straub, Sarah
dc.contributor.authorAndersson, Christin
dc.contributor.authorAntonell, Anna
dc.contributor.authorArighi, Andrea
dc.contributor.authorBalasa, Mircea
dc.contributor.authorBarandiaran, Myriam
dc.contributor.authorBargalló, Nuria
dc.contributor.authorBartha, Robart
dc.contributor.authorBender, Benjamin
dc.contributor.authorBuratti, Emanuele
dc.contributor.authorBenussi, Luisa
dc.contributor.authorBertoux, Maxime
dc.contributor.authorBinetti, Giuliano
dc.contributor.authorBlack, Sandra
dc.contributor.authorBocchetta, Martina
dc.contributor.authorBorrego-Ecija, Sergi
dc.contributor.authorBras, Jose
dc.contributor.authorBruffaerts, Rose
dc.contributor.authorCañada, Marta
dc.contributor.authorCantoni, Valentina
dc.contributor.authorCaroppo, Paola
dc.contributor.authorCash, David
dc.contributor.authorCastelo-Branco, Miguel
dc.contributor.authorConvery, Rhian
dc.contributor.authorCope, Thomas
dc.contributor.authorDeramecourt, Vincent
dc.contributor.authorDi Fede, Giuseppe
dc.contributor.authorDíez, Alina
dc.contributor.authorFenoglio, Chiara
dc.contributor.authorFerreira, Catarina B.
dc.contributor.authorFox, Nick
dc.contributor.authorFreedman, Morris
dc.contributor.authorFumagalli, Giorgio
dc.contributor.authorFunkiewiez, Aurélie
dc.contributor.authorGabilondo, Alazne
dc.contributor.authorGasparotti, Roberto
dc.contributor.authorGauthier, Serge
dc.contributor.authorAlberici, Antonella
dc.contributor.authorGiaccone, Giorgio
dc.contributor.authorGorostidi, Ana
dc.contributor.authorGreaves, Caroline
dc.contributor.authorGuerreiro, Rita
dc.contributor.authorIndakoetxea, Begoña
dc.contributor.authorJelic, Vesna
dc.contributor.authorKarnath, Hans-Otto
dc.contributor.authorKeren, Ron
dc.contributor.authorKuchcinski, Gregory
dc.contributor.authorLangheinrich, Tobias
dc.contributor.authorLebouvier, Thibaud
dc.contributor.authorLeitão, Maria João
dc.contributor.authorLladó, Albert
dc.contributor.authorMaruta, Carolina
dc.contributor.authorMeeter, Lieke
dc.contributor.authorMiltenberger-Miltenyi, Gabriel
dc.contributor.authorvan Minkelen, Rick
dc.contributor.authorMitchell, Sara
dc.contributor.authorMoore, Katrina
dc.contributor.authorNicholas, Jennifer
dc.contributor.authorOlives, Jaume
dc.contributor.authorOurselin, Sebastien
dc.contributor.authorPadovani, Alessandro
dc.contributor.authorPanman, Jessica
dc.contributor.authorPapma, Janne M.
dc.date.accessioned2023-11-28T15:23:45Z
dc.date.available2023-11-28T15:23:45Z
dc.date.issued2023
dc.description© The Author(s) 2023. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.pt_PT
dc.description.abstractBackground: Plasma biomarkers reflecting the pathology of frontotemporal dementia would add significant value to clinical practice, to the design and implementation of treatment trials as well as our understanding of disease mechanisms. The aim of this study was to explore the levels of multiple plasma proteins in individuals from families with genetic frontotemporal dementia. Methods: Blood samples from 693 participants in the GENetic Frontotemporal Dementia Initiative study were analysed using a multiplexed antibody array targeting 158 proteins. Results: We found 13 elevated proteins in symptomatic mutation carriers, when comparing plasma levels from people diagnosed with genetic FTD to healthy non-mutation controls and 10 proteins that were elevated compared to presymptomatic mutation carriers. Conclusion: We identified plasma proteins with altered levels in symptomatic mutation carriers compared to non-carrier controls as well as to presymptomatic mutation carriers. Further investigations are needed to elucidate their potential as fluid biomarkers of the disease process.pt_PT
dc.description.sponsorshipOpen access funding provided by Karolinska Institute. C.G. received funding from EU Joint Programme—Neurodegenerative Disease Research -Prefrontals Vetenskapsrådet Dnr 529–2014-7504, Vetenskapsrådet 2015–02926, Vetenskapsrådet 2018–02754, the Swedish FTD Inititative-Schörling Foundation, Alzheimer Foundation, Brain Foundation, Dementia Foundation and Region Stockholm ALF-project. PN received funding from KTH Center for Applied Precision Medicine (KCAP) funded by the Erling-Persson Family Foundation, the Swedish FTD Inititative-Schörling Foundation and Åhlén foundation. D.G. received support from the EU Joint Programme—Neurodegenerative Disease Research and the Italian Ministry of Health (PreFrontALS) grant 733051042. E.F. has received funding from a Canadian Institute of Health Research grant #327387. F.M. received funding from the Tau Consortium and the Center for Networked Biomedical Research on Neurodegenerative Disease. J.B.R. has received funding from the Welcome Trust (103838) and is supported by the Cambridge University Centre for Frontotemporal Dementia, the Medical Research Council (SUAG/051 G101400) and the National Institute for Health Research Cambridge Biomedical Research Centre (BRC-1215–20014). J.C.V.S. was supported by the Dioraphte Foundation grant 09–02-03–00, Association for Frontotemporal Dementias Research Grant 2009, Netherlands Organization for Scientific Research grant HCMI 056–13-018, ZonMw Memorabel (Deltaplan Dementie, project number 733 051 042), Alzheimer Nederland and the Bluefield Project. J.D.R. is supported by the Bluefield Project and the National Institute for Health and Care Research University College London Hospitals Biomedical Research Centre, and has received funding from an MRC Clinician Scientist Fellowship (MR/M008525/1) and a Miriam Marks Brain Research UK Senior Fellowship. M.M. has received funding from a Canadian Institute of Health Research operating grant and the Weston Brain Institute and Ontario Brain Institute. M.O. has received funding from Germany’s Federal Ministry of Education and Research (BMBF). R.S-V. is supported by Alzheimer’s Research UK Clinical Research Training Fellowship (ARUK-CRF2017B-2) and has received funding from Fundació Marató de TV3, Spain (grant no. 20143810). R.V. has received funding from the Mady Browaeys Fund for Research into Frontotemporal Dementia. This work was also supported by the EU Joint Programme—Neurodegenerative Disease Research GENFI-PROX grant [2019–02248; to J.D.R., M.O., B.B., C.G., J.C.V.S. and M.S.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMol Neurodegener. 2023 Nov 15;18(1):85pt_PT
dc.identifier.doi10.1186/s13024-023-00677-6pt_PT
dc.identifier.eissn1750-1326
dc.identifier.urihttp://hdl.handle.net/10451/60956
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringer Naturept_PT
dc.relation.publisherversionhttps://molecularneurodegeneration.biomedcentral.com/pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectC9orf72pt_PT
dc.subjectFrontotemporal dementiapt_PT
dc.subjectGRNpt_PT
dc.subjectMAPTpt_PT
dc.subjectNeurodegenerationpt_PT
dc.subjectPlasma biomarkerspt_PT
dc.titleAltered plasma protein profiles in genetic FTD – a GENFI studypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue1pt_PT
oaire.citation.titleMolecular Neurodegenerationpt_PT
oaire.citation.volume18pt_PT
person.familyNameVerdelho
person.familyNamede Mendonça
person.familyNameCastelo-Branco
person.familyNameda Silva Ferreira
person.familyNameMaruta
person.familyNameMiltenberger-Miltenyi
person.givenNameAna
person.givenNameAlexandre
person.givenNameMiguel
person.givenNameCatarina Beatriz
person.givenNameCarolina
person.givenNameGabriel
person.identifier351267
person.identifier.ciencia-idFC14-938F-EBBD
person.identifier.ciencia-id1615-41B4-0848
person.identifier.ciencia-id7A12-48FE-7B56
person.identifier.ciencia-idAC14-0471-33EA
person.identifier.ciencia-id4B1D-5F59-6221
person.identifier.ciencia-idAE16-3A8D-0392
person.identifier.orcid0000-0003-4945-4946
person.identifier.orcid0000-0002-0488-1453
person.identifier.orcid0000-0003-4364-6373
person.identifier.orcid0000-0002-2538-1650
person.identifier.orcid0000-0003-3359-379X
person.identifier.orcid0000-0003-0224-1281
person.identifier.ridF-3866-2019
person.identifier.scopus-author-id6602902026
person.identifier.scopus-author-id7003320823
person.identifier.scopus-author-id6701423628
person.identifier.scopus-author-id35327513800
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication11ec545d-3044-4ffd-b658-578d00f82d2a
relation.isAuthorOfPublication53ca3547-99ce-4b68-9330-7879a54c47b7
relation.isAuthorOfPublication16245106-f8db-49a9-be95-8806aa05dfad
relation.isAuthorOfPublicationdd8f6018-0f48-4b76-811b-2a201a8938f9
relation.isAuthorOfPublication4a8bdaf9-480a-4836-ac4b-c80c3b4e0391
relation.isAuthorOfPublication58c7f5b7-9f9d-42b6-9b39-c53dd40a79c7
relation.isAuthorOfPublication.latestForDiscoverydd8f6018-0f48-4b76-811b-2a201a8938f9

Ficheiros

Principais
A mostrar 1 - 1 de 1
Miniatura
Nome:
Plasma_protein.pdf
Tamanho:
1.07 MB
Formato:
Adobe Portable Document Format
Ver/Abrir
Licença
A mostrar 1 - 1 de 1
Miniatura indisponível
Nome:
license.txt
Tamanho:
1.2 KB
Formato:
Item-specific license agreed upon to submission
Descrição:
Ver/Abrir

Coleções

FM - Artigos em Revistas Internacionais
IMM - Artigos em Revistas Internacionais