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Advisor(s)
Abstract(s)
Introdução: A Síndrome do intestino irritável é uma das doenças funcionais gastrointestinais mais frequentes no mundo, afetando dezenas de milhões de pessoas. A doença pode ter como base vários subtipos e, portanto, uma grande variedade de quadros clínicos. No entanto, ainda não estamos perto de perceber completamente a fisiopatologia desta síndrome, a ligação a fatores genéticos ou até a diferença de incidência e prevalência geográfica. Não havendo cura, existe uma grande necessidade ou de desenvolvimento de novos fármacos ou realização de ensaio com fármacos já existentes que possam ter efeito considerável na doença.
Objetivo: Para este efeito, esta revisão baseada na melhor evidência propõe olhar para o conhecimento e dados mais recentes que temos acerca da utilização de antidepressivos no tratamento desta doença.
Métodos: Para tal, realizou-se uma pesquisa por artigos na base de dados eletrónica PubMed, dando importância às meta-análises e artigos de revisão mais recentes sobre assunto. Também foi dada importância à revisão de alguns conceitos chave sobre o tema.
Resultados: Neste artigo, demonstra-se que a evidência à volta da utilização de antidepressivos nesta síndrome é, no geral, fraca e não consensual, havendo poucos ensaios clínicos nos últimos anos a contribuir para esta temática, o que mostra a necessidade de investir nesta área para se poder entender melhor se os antidepressivos podem ser uma alternativa a usar nesta doença.
Introduction: Irritable Bowel Syndrome is one of the most frequent functional gastrointestinal disorders in the world, afflicting tens of millions of people. The disease can be of several subtypes, hence having a big variety of clinical manifestations. However, we are still not close to completely understanding the pathophysiology of this syndrome, its connection to genetic factors or even the difference of geographical incidence and prevalence. Because there is not a cure, there is a great necessity for either the development of new pharmaceuticals or the execution of clinical trials with already existing drugs that might have a considerable effect on the disease. Objective: To this effect, this systematic review proposes to look to the most recent knowledge and data that we have concerning the utilization of antidepressants in the treatment of this disease. Methods: In accordance with this, a research was made for articles in the electronic database PubMed, giving importance to the more recent meta-analysis and review articles about this issue. Importance was also given to the review of some key concepts about this theme. Results: In this article, it is demonstrated that the evidence around the utilization of antidepressants in this syndrome is, in general, weak, and non-consensual, there being few clinical trials the last few years to contribute to this thematic, which shows the necessity to invest in this area in order to better understand if antidepressants can be an alternative to use in this disease.
Introduction: Irritable Bowel Syndrome is one of the most frequent functional gastrointestinal disorders in the world, afflicting tens of millions of people. The disease can be of several subtypes, hence having a big variety of clinical manifestations. However, we are still not close to completely understanding the pathophysiology of this syndrome, its connection to genetic factors or even the difference of geographical incidence and prevalence. Because there is not a cure, there is a great necessity for either the development of new pharmaceuticals or the execution of clinical trials with already existing drugs that might have a considerable effect on the disease. Objective: To this effect, this systematic review proposes to look to the most recent knowledge and data that we have concerning the utilization of antidepressants in the treatment of this disease. Methods: In accordance with this, a research was made for articles in the electronic database PubMed, giving importance to the more recent meta-analysis and review articles about this issue. Importance was also given to the review of some key concepts about this theme. Results: In this article, it is demonstrated that the evidence around the utilization of antidepressants in this syndrome is, in general, weak, and non-consensual, there being few clinical trials the last few years to contribute to this thematic, which shows the necessity to invest in this area in order to better understand if antidepressants can be an alternative to use in this disease.
Description
Trabalho Final do Curso de Mestrado Integrado em Medicina, Faculdade de Medicina, Universidade de Lisboa, 2021
Keywords
Síndrome do intestino irritável Antidepressivos tricíclicos Inibidores seletivos de recaptação de serotonina e noradrenalina Antidepressivos atípicos Psiquiatria