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Emergence and Spread of Cephalosporinases in Wildlife: A Review
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Orientador(es)
Resumo(s)
In the last decade, detection of antibiotic resistant bacteria from wildlife has received
increasing interest, due to the potential risk posed by those bacteria to wild animals, livestock or
humans at the interface with wildlife, and due to the ensuing contamination of the environment.
According toWorld Health Organization, cephalosporins are critically important antibiotics to human
health. However, acquired resistance to -lactams is widely distributed and is mainly mediated by
extended-spectrum beta-lactamase and AmpC beta-lactamases, such as cephalosporinases. This work
thus aimed to compile and analyse the information available on the emergence and dissemination
of cephalosporinases in wildlife worldwide. Results suggest a serious scenario, with reporting
of cephalosporinases in 46 countries from all continents (52% in Europe), across 188 host species,
mainly birds and mammals, especially gulls and ungulates. The most widely reported cephalosporinases,
CTX-M-1, CTX-M-14, CTX-M-15 and CMY-2, were also the most common in wild animals, in
agreement with their ubiquity in human settings, including their association to high-risk clones of
Escherichia coli (E. coli), such as the worldwide distributed CTX-M-15/ST131 E. coli. Altogether, our
findings show that anthropogenic activities affect the whole ecosystem and that public policies pro-moting animal and environmental surveillance, as well as mitigation measures to avoid antimicrobial
misuse and AMR spread, are urgently needed to be out in practise.
Descrição
Palavras-chave
one health wildlife cephalosporinases ESBL AmpC CTX-M
Contexto Educativo
Citação
Palmeira, J.D.; Cunha, M.V.; Carvalho, J.; Ferreira, H.; Fonseca, C.; Torres, R.T. Emergence and Spread of Cephalosporinases in Wildlife: A Review. Animals 2021, 11, 1765. https://doi.org/10.3390/ani11061765
Editora
MDPI