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Emergence and Spread of Cephalosporinases in Wildlife: A Review

2021-06Artigo científico Acesso aberto
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dc.contributor.authorPalmeira, Josman D.
dc.contributor.authorV. Cunha, Mónica
dc.contributor.authorCarvalho, João
dc.contributor.authorFerreira, Helena
dc.contributor.authorFonseca, Carlos
dc.contributor.authorTorres, Rita T.
dc.date.accessioned2021-08-13T11:41:50Z
dc.date.available2021-08-13T11:41:50Z
dc.date.issued2021-06
dc.description.abstractIn the last decade, detection of antibiotic resistant bacteria from wildlife has received increasing interest, due to the potential risk posed by those bacteria to wild animals, livestock or humans at the interface with wildlife, and due to the ensuing contamination of the environment. According toWorld Health Organization, cephalosporins are critically important antibiotics to human health. However, acquired resistance to -lactams is widely distributed and is mainly mediated by extended-spectrum beta-lactamase and AmpC beta-lactamases, such as cephalosporinases. This work thus aimed to compile and analyse the information available on the emergence and dissemination of cephalosporinases in wildlife worldwide. Results suggest a serious scenario, with reporting of cephalosporinases in 46 countries from all continents (52% in Europe), across 188 host species, mainly birds and mammals, especially gulls and ungulates. The most widely reported cephalosporinases, CTX-M-1, CTX-M-14, CTX-M-15 and CMY-2, were also the most common in wild animals, in agreement with their ubiquity in human settings, including their association to high-risk clones of Escherichia coli (E. coli), such as the worldwide distributed CTX-M-15/ST131 E. coli. Altogether, our findings show that anthropogenic activities affect the whole ecosystem and that public policies pro-moting animal and environmental surveillance, as well as mitigation measures to avoid antimicrobial misuse and AMR spread, are urgently needed to be out in practise.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationPalmeira, J.D.; Cunha, M.V.; Carvalho, J.; Ferreira, H.; Fonseca, C.; Torres, R.T. Emergence and Spread of Cephalosporinases in Wildlife: A Review. Animals 2021, 11, 1765. https://doi.org/10.3390/ani11061765pt_PT
dc.identifier.doi10.3390/ani11061765pt_PT
dc.identifier.issn2076-2615
dc.identifier.urihttp://hdl.handle.net/10451/49300
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationFEDER project OCI-01-0145-FEDER-030310pt_PT
dc.relationFCT/MCTESpt_PT
dc.relationFCT UID/AMB/50017/2019pt_PT
dc.relationFCT UIDB/00329/20192020pt_PT
dc.relationFCT UIDB/04046/2020pt_PT
dc.relationFCT UIDP/04378/2020pt_PT
dc.relationFCT UIDB/04378/2020pt_PT
dc.relation.publisherversionhttps://www.mdpi.com/2076-2615/11/6/1765pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectone healthpt_PT
dc.subjectwildlifept_PT
dc.subjectcephalosporinasespt_PT
dc.subjectESBLpt_PT
dc.subjectAmpCpt_PT
dc.subjectCTX-Mpt_PT
dc.titleEmergence and Spread of Cephalosporinases in Wildlife: A Reviewpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue6pt_PT
oaire.citation.startPage1765pt_PT
oaire.citation.titleAnimalspt_PT
oaire.citation.volume11pt_PT
person.familyNameCunha
person.givenNameMonica V.
person.identifier348477
person.identifier.ciencia-id5616-E715-2F31
person.identifier.orcid0000-0003-0401-0276
person.identifier.ridD-5544-2011
person.identifier.scopus-author-id7102711216
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationa1b365bb-7421-4bf5-9cde-62b74c170e69
relation.isAuthorOfPublication.latestForDiscoverya1b365bb-7421-4bf5-9cde-62b74c170e69

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