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Prevalência e caracterização da densidade vascular dos tumores testiculares em cães
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Abstract(s)
Os tumores testiculares representam o segundo tipo de alterações oncológicas mais
comuns em cães. Os três tipos de tumores testiculares diagnosticados com maior
frequência são os leydigomas, seminomas e sertolinomas. Para estudar a prevalência
dos tumores testiculares em cães, assim como o tipo de tumor que aparece mais
frequentemente, foram recolhidas informações sobre os cães registados no HEV-FMV
(n=31710) e dos cães com diagnóstico histopatológico de tumor testicular pelo
Laboratório de Anatomia Patológica da Faculdade de Medicina Veterinária (n=246),
durante o período de 7 anos. A prevalência de tumores testiculares foi de 0,8%, sendo
que os leydigomas foram o tipo de neoplasia mais frequente, diagnosticados em 153
cães (62,3%) (p< 0,001). A média da idade dos animais diagnosticados com tumor
testicular foi de 10,69 ± 2,7 anos e a raça que apresentou um risco estimado mais
elevado de desenvolver tumores testiculares foi a Golden Retriever.
Com o objetivo de caracterizar o padrão vascular dos 3 tipos de tumores
testiculares mais comuns, foi feita a avaliação dos testículos de 13 cães por ecografia
antes da orquiectomia, e posteriormente por imunoflurescência (marcação com os
anticorpos anti-CD31 e anti-SMA). Infelizmente, em termo ecográficos não foi possível
demonstrar um padrão vascular discriminativo para os diferentes tipos de tumor. No
entanto, o leydigoma demostrou ser o tipo de tumor testicular com maior densidade
vascular (p<0,01) quando comparado com tecido testicular normal ou atrofiado ou com
o seminoma, através do método de imunofluorescência.
ABSTRACT - PREVALENCE AND VASCULAR DENSITY CHARACTERIZATION OF TESTICULAR TUMORS IN DOGS - Testicular tumors represent the second type of most common neoplasia in dogs. The three types of testicular tumors most frequently diagnosed are leydigomas, seminomas and sertolinomas. To study the prevalence of testicular tumors in dogs, as well as the type of tumor that appears more frequently, we collected the information about dogs registered in the HEV-FMV (n=31710) and dogs with histopathological diagnosis of testicular tumor done by the Laboratory of Pathological Anatomy of the Faculty of Veterinary Medicine (n=246), during the period of 7 years. The prevalence of testicular tumors was 0.8%, and the leydigomas were the most frequent type of neoplasm, diagnosed in 153 dogs (62,3%) (p< 0,001). The mean age of animals diagnosed with testicular tumor was 10.69 ± 2.7 years and the breed that had a higher estimated risk of developing testicular tumor was Golden Retriever. In order to characterize the vascular pattern of the 3 most common types of testicular tumors, testicles of 13 dogs were evaluated by ultrasound before orchiectomy and previously by immunoflurescence (marking made with antibodies anti-cd31 and antisma). Unfortunately, in ultrasonography terms, it was not possible to demonstrate a vascular pattern characteristic of the different tumors. However, leydigoma proved to be the type of testicular tumor with higher vascular density (p<0.01) when compared with normal or atrophy testicular tissue or with seminoma, using the immunofluorescence method.
ABSTRACT - PREVALENCE AND VASCULAR DENSITY CHARACTERIZATION OF TESTICULAR TUMORS IN DOGS - Testicular tumors represent the second type of most common neoplasia in dogs. The three types of testicular tumors most frequently diagnosed are leydigomas, seminomas and sertolinomas. To study the prevalence of testicular tumors in dogs, as well as the type of tumor that appears more frequently, we collected the information about dogs registered in the HEV-FMV (n=31710) and dogs with histopathological diagnosis of testicular tumor done by the Laboratory of Pathological Anatomy of the Faculty of Veterinary Medicine (n=246), during the period of 7 years. The prevalence of testicular tumors was 0.8%, and the leydigomas were the most frequent type of neoplasm, diagnosed in 153 dogs (62,3%) (p< 0,001). The mean age of animals diagnosed with testicular tumor was 10.69 ± 2.7 years and the breed that had a higher estimated risk of developing testicular tumor was Golden Retriever. In order to characterize the vascular pattern of the 3 most common types of testicular tumors, testicles of 13 dogs were evaluated by ultrasound before orchiectomy and previously by immunoflurescence (marking made with antibodies anti-cd31 and antisma). Unfortunately, in ultrasonography terms, it was not possible to demonstrate a vascular pattern characteristic of the different tumors. However, leydigoma proved to be the type of testicular tumor with higher vascular density (p<0.01) when compared with normal or atrophy testicular tissue or with seminoma, using the immunofluorescence method.
Description
Dissertação de Mestrado Integrado em Medicina Veterinária
Keywords
Cão Tumor testicular Ecografia Imunoflurescência Dog Testicular tumor Ultrasound Immunofluorescence
Pedagogical Context
Citation
Alvarado CCSR 2020. Prevalência e caracterização da densidade vascular dos tumores testiculares em cães [dissertação de mestrado]. Lisboa: FMV-Universidade de Lisboa
Publisher
Universidade de Lisboa, Faculdade de Medicina Veterinária