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Neuromelanin magnetic resonance imaging of the substantia nigra in LRRK2-related Parkinson's disease

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dc.contributor.authorCorreia Guedes, Leonor
dc.contributor.authorReimão, Sofia
dc.contributor.authorPaulino, Patrícia
dc.contributor.authorNunes, Rita G.
dc.contributor.authorBouça-Machado, Raquel
dc.contributor.authorAbreu, Daisy
dc.contributor.authorGonçalves, Nilza
dc.contributor.authorSoares, Tiago
dc.contributor.authorFabbri, Margherita
dc.contributor.authorGodinho, Catarina
dc.contributor.authorPita Lobo, Patrícia
dc.contributor.authorNeutel, Dulce
dc.contributor.authorQuadri, Marialuisa
dc.contributor.authorCoelho, Miguel
dc.contributor.authorRosa, Mário Miguel
dc.contributor.authorCampos, Jorge
dc.contributor.authorOuteiro, Tiago
dc.contributor.authorSampaio, Cristina
dc.contributor.authorBonifati, Vincenzo
dc.contributor.authorFerreira, Joaquim J
dc.date.accessioned2022-09-08T14:56:51Z
dc.date.available2022-09-08T14:56:51Z
dc.date.issued2017
dc.description© John Wiley & Sons, Inc. All rights reserved.pt_PT
dc.description.abstractSpecific T-weighted MRI sequences are able to detect SN neuromelanin (NM) signal changes and accurately discriminate Parkinson’s disease (PD) patients from controls. The study of NM-MRI in PD patients carrying a LRRK2 gene mutation (LRRK2-PD) could contribute to further uncover LRRK2-associated phenotype. Albeit considered to largely overlap idiopathic PD (iPD), differences have been described. Furthermore, the identification of a biomarker of neurodegeneration in LRRK2-PD can eventually support studies in asymptomatic carriers. Castellanos and colleagues5 found NM-MRI SN volumes significantly reduced in both idiopathic and LRRK2-PD (3 G2019S and 4 R1441G PD patients).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMov Disord. 2017 Sep;32(9):1331-1333pt_PT
dc.identifier.doi10.1002/mds.27083pt_PT
dc.identifier.eissn1531-8257
dc.identifier.issn0885-3185
dc.identifier.urihttp://hdl.handle.net/10451/54389
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWileypt_PT
dc.relation.publisherversionhttps://movementdisorders.onlinelibrary.wiley.com/journal/15318257pt_PT
dc.titleNeuromelanin magnetic resonance imaging of the substantia nigra in LRRK2-related Parkinson's diseasept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage1333pt_PT
oaire.citation.issue9pt_PT
oaire.citation.startPage1331pt_PT
oaire.citation.titleMovement Disorderspt_PT
oaire.citation.volume32pt_PT
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