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Publicação
Neuromelanin magnetic resonance imaging of the substantia nigra in LRRK2-related Parkinson's disease
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Orientador(es)
Resumo(s)
Specific T-weighted MRI sequences are able to detect SN neuromelanin (NM) signal changes and accurately discriminate Parkinson’s disease (PD) patients from controls. The study of NM-MRI in PD patients carrying a LRRK2 gene mutation (LRRK2-PD) could contribute to further uncover LRRK2-associated phenotype. Albeit considered to largely overlap idiopathic PD (iPD), differences have been described. Furthermore, the identification of a biomarker of neurodegeneration in LRRK2-PD can eventually support studies in asymptomatic carriers. Castellanos and colleagues5 found NM-MRI SN volumes significantly reduced in both idiopathic and LRRK2-PD (3 G2019S and 4 R1441G PD patients).
Descrição
© John Wiley & Sons, Inc. All rights reserved.
Palavras-chave
Contexto Educativo
Citação
Mov Disord. 2017 Sep;32(9):1331-1333
Editora
Wiley