A carregar...
Publicação
Carcinoma mamário felino : estudo retrospetivo sobre a relação entre os subtipos histológicos, a metastização e a eficácia do tratamento adjuvante em 36 gatas
| Nome: | Descrição: | Tamanho: | Formato: | |
|---|---|---|---|---|
| 1.36 MB | Adobe PDF |
Orientador(es)
Resumo(s)
O carcinoma mamário representa o terceiro tipo de tumor mais comum na espécie felina e afeta, principalmente, gatas adultas e seniores. Trata-se de um tumor altamente maligno e rapidamente fatal, devido à sua grande capacidade de metastização e tendência para recidiva, apresentando tempo médio de sobrevivência de 6 a 18 meses. Os subtipos histológicos mais frequentemente diagnosticados são o tubulopapilífero, o tubular, o sólido, o cribiforme e o in situ. A metastização pode ocorrer entre 50% a 90% dos casos e os locais mais afetados são os linfonodos regionais e os pulmões. O método de diagnóstico de eleição é a análise histopatológica de biópsia obtida através de mastectomia. A quimioterapia, incluindo a administração de inibidores da tirosina quinase, é utilizada como tratamento adjuvante à remoção cirúrgica. O prognóstico desta doença é reservado a mau, sendo que o tamanho do tumor, o subtipo e o grau histológicos e o estadiamento clínico são fatores de prognóstico relevantes. Este estudo teve como objetivo avaliar a possível influência dos subtipos histológicos na metastização e na eficácia do tratamento adjuvante. Assim, foram incluídas 36 gatas diagnosticadas com carcinoma mamário no Hospital Escolar Veterinário da Faculdade de Medicina Veterinária da Universidade de Lisboa entre 2011 e 2023. A idade média foi de 11,9 anos e a raça predominante foi a Doméstico de Pelo Curto (75,0% 27/36). Nesta amostra, foram diagnosticados 67 carcinomas mamários e 11 subtipos histológicos diferentes, tendo sido mais frequente o tubulopapilífero (41,8% 28/67), seguido do tubular (25,4% 17/67), do sólido (9,0% 6/67) e do cribiforme (7,5% 5/67). A metastização ocorreu em 31 gatas (86,1%) e os principais locais foram os linfonodos regionais (80,6% 25/31) e os pulmões (64,5% 20/31). Os tratamentos adjuvantes realizados foram a quimioterapia endovenosa de alta dose (QEAD), a quimioterapia metronómica de baixa dose (QMBD) e o fosfato de toceranib (FT). De acordo com os resultados obtidos, as gatas com carcinoma tubulopapilífero apresentaram menor probabilidade de desenvolver metastização pulmonar, comparativamente com os outros subtipos (P = 0,030). Relativamente à eficácia do tratamento adjuvante, não foram encontradas diferenças estatisticamente significativas na progressão da doença e na sobrevivência entre os diferentes subtipos. No entanto, poderá ter havido um efeito benéfico da realização do tratamento no prognóstico das gatas com os subtipos sólido e tubular
ABSTRACT - Feline Mammary Carcinoma: Retrospective Study on the Relationship between Histological Subtypes, Metastasis and the Efficacy of Adjuvant Treatment in 36 Female Cats - Mammary carcinoma represents the third most common type of tumor in the feline species, primarily affecting adult and senior female cats. This tumor is highly malignant and rapidly fatal due to its significant capacity for metastasis and tendency to recur, with an average survival between 6 to 18 months. The most frequently diagnosed histological subtypes are tubulopapillary, tubular, solid, cribriform, and in situ. Metastasis can occur in 50% to 90% of cases, with the most affected sites being regional lymph nodes and the lungs. The diagnostic method of choice is histopathological analysis of a biopsy obtained through mastectomy. Chemotherapy, including the administration of tyrosine kinase inhibitors, is used as adjuvant treatment following surgical removal. The prognosis for this disease is reserved to poor, with tumor size, histological subtypes and grade and clinical staging being relevant prognostic factors. This study aimed to evaluate the potential influence of histological subtypes on metastasis and on the efficacy of adjuvant treatment. Thus, 36 female cats diagnosed with mammary carcinoma at the Hospital Escolar Veterinário da Faculdade de Medicina Veterinária da Universidade de Lisboa, between 2011 and 2023 were included. The average age was 11.9 years, and the predominant breed was Domestic Shorthair (75.0% 27/36). In this sample, 67 mammary carcinomas and 11 different histological subtypes were diagnosed, with the most frequent being tubulopapillary (41.8% 28/67), followed by tubular (25.4% 17/67), solid (9.0% 6/67), and cribriform (7.5% 5/67). Metastasis occurred in 31 cats (86.1%), with the primary sites being regional lymph nodes (80.6% 25/31) and lungs (64.5% 20/31). The adjuvant treatments administered were high-dose intravenous chemotherapy, low-dose metronomic chemotherapy, and toceranib phosphate. According to the results obtained, cats with tubulopapillary carcinoma showed a lower probability of developing pulmonary metastasis compared to other subtypes (P = 0.030). Regarding the efficacy of adjuvant treatment, no statistically significant differences were found in disease progression and survival among the different subtypes. However, there may have been a beneficial effect of the treatment on the prognosis of cats with solid and tubular subtypes
ABSTRACT - Feline Mammary Carcinoma: Retrospective Study on the Relationship between Histological Subtypes, Metastasis and the Efficacy of Adjuvant Treatment in 36 Female Cats - Mammary carcinoma represents the third most common type of tumor in the feline species, primarily affecting adult and senior female cats. This tumor is highly malignant and rapidly fatal due to its significant capacity for metastasis and tendency to recur, with an average survival between 6 to 18 months. The most frequently diagnosed histological subtypes are tubulopapillary, tubular, solid, cribriform, and in situ. Metastasis can occur in 50% to 90% of cases, with the most affected sites being regional lymph nodes and the lungs. The diagnostic method of choice is histopathological analysis of a biopsy obtained through mastectomy. Chemotherapy, including the administration of tyrosine kinase inhibitors, is used as adjuvant treatment following surgical removal. The prognosis for this disease is reserved to poor, with tumor size, histological subtypes and grade and clinical staging being relevant prognostic factors. This study aimed to evaluate the potential influence of histological subtypes on metastasis and on the efficacy of adjuvant treatment. Thus, 36 female cats diagnosed with mammary carcinoma at the Hospital Escolar Veterinário da Faculdade de Medicina Veterinária da Universidade de Lisboa, between 2011 and 2023 were included. The average age was 11.9 years, and the predominant breed was Domestic Shorthair (75.0% 27/36). In this sample, 67 mammary carcinomas and 11 different histological subtypes were diagnosed, with the most frequent being tubulopapillary (41.8% 28/67), followed by tubular (25.4% 17/67), solid (9.0% 6/67), and cribriform (7.5% 5/67). Metastasis occurred in 31 cats (86.1%), with the primary sites being regional lymph nodes (80.6% 25/31) and lungs (64.5% 20/31). The adjuvant treatments administered were high-dose intravenous chemotherapy, low-dose metronomic chemotherapy, and toceranib phosphate. According to the results obtained, cats with tubulopapillary carcinoma showed a lower probability of developing pulmonary metastasis compared to other subtypes (P = 0.030). Regarding the efficacy of adjuvant treatment, no statistically significant differences were found in disease progression and survival among the different subtypes. However, there may have been a beneficial effect of the treatment on the prognosis of cats with solid and tubular subtypes
Descrição
Dissertação de Mestrado Integrado em Medicina Veterinária, área científica de Clínica
Palavras-chave
Carcinoma mamário Gatas Subtipos histológicos Metastização Tratamento adjuvante Mammary carcinoma Female cats Histological subtypes Metastasis Adjuvant treatment
Contexto Educativo
Citação
Bernardo ARNH. 2024. Carcinoma mamário felino : estudo retrospetivo sobre a relação entre os subtipos histológicos, a metastização e a eficácia do tratamento adjuvante em 36 gatas [dissertação de mestrado]. Lisboa: FMV-Universidade de Lisboa
Editora
Universidade de Lisboa, Faculdade de Medicina Veterinária