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Estudo clínico de utilização de anti-histamínico na doença respiratória bovina
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A doença respiratória bovina é uma condição comum em vitelos leiteiros e, apesar dos esforços realizados para a combater, o seu tratamento continua a apresentar desafios. É fundamental identificar possíveis melhorias nesse processo para aumentar a sua eficácia. O principal objetivo do presente estudo foi avaliar a eficácia da utilização de um anti-histamínico, maleato de clorfenamina (Ancesol®) no tratamento da doença respiratória bovina, utilizando sistemas de pontuação clínicos para a avaliação dos sinais clínicos mais comumente associados a esta doença, e utilização de registos das amamentadoras automáticas para avaliação dos indicadores alimentares, percentagem de consumo, velocidade de ingestão, ganho médio diário e visitas sem consumo. Para o presente estudo foram avaliados 60 vitelos de leite, com idades entre os 7 e os 88 dias, pertencentes a uma única exploração leiteira, localizada na zona de Benavente. Os vitelos, com diagnóstico de doença respiratória, foram distribuídos aleatoriamente por dois grupos, o grupo controlo (n=31) e o grupo Ancesol (n=29). Todos os vitelos foram avaliados durante três dias após o diagnóstico, tendo sido registadas as pontuações clínicas dos sinais clínicos: corrimento nasal, corrimento ocular, posição das orelhas, tosse, temperatura retal e consistência das fezes. Os indicadores alimentares, percentagem de consumo, velocidade de ingestão, ganho médio diário e visitas sem consumo, foram obtidos através das amamentadoras automáticas, no período de 5 dias antes do diagnóstico de doença respiratória bovina e 15 dias após o diagnóstico. As diferenças para as médias relativas às pontuações clínicas: corrimento nasal (valor de p = 0,94), posição das orelhas (valor de p = 0,45), tosse (valor de p = 0,71), temperatura (valor de p =0,92) e fecal (valor de p =0,58) entre os animais dos dois grupos não foram estatisticamente significativas. As diferenças nas médias relativas à percentagem de consumo entre o grupo controlo e o grupo Ancesol, mostraram ser estatisticamente significativas (valor de p< 0,001). Contudo as diferenças nas médias relativas à velocidade de ingestão (valor de p = 0,53), ao ganho médio diário (valor de p = 0,13) e às visitas sem consumo (valor de p = 0,65) não foram estatisticamente significativas. Face aos resultados obtidos este estudo não deu indicações favoráveis quanto à utilização deste anti-histamínico no tratamento da doença respiratória bovina, contudo seria vantajoso a realização de estudos com uma amostra populacional maior e que abrangessem mais do que uma exploração
ABSTRACT - CLINICAL STUDY ON THE USE OF ANTIHISTAMINE IN BOVINE RESPIRATORY DISEASE - Bovine respiratory disease is a common condition in dairy calves and, despite efforts to contest it, its treatment continues to present challenges. It is essential to identify possible improvements in this process to increase its effectiveness. The main objective of this trial was to evaluate the effectiveness of using an antihistamine, chlorphenamine maleate (Ancesol®) in the treatment of bovine respiratory disease, using clinical scoring systems to evaluate the clinical signs most associated with this disease, and use of records from automated milk feeders, to evaluate dietary indicators percentage of consumption, speed of ingestion, average daily gain and visits without consumption. For the present study, 60 dairy calves were evaluated, aged between 7 and 88 days, belonging to a single dairy farm, located in the Benavente area. The calves, diagnosed with respiratory disease, were randomly distributed into two groups, the control group (n=31) and the Ancesol group (n=29). All calves were evaluated for three days after diagnosis, and clinical scores of the following clinical signs were recorded: nasal discharge, ocular discharge, ear position, cough, rectal temperature and stool consistency. The dietary indicators, percentage of consumption, speed of ingestion, average daily gain and visits without consumption, were obtained through the automated milk feeders, during the period of 5 days before the diagnosis of bovine respiratory disease and 15 days after the diagnosis. The differences in means relative to clinical scores: nasal discharge (p-value = 0.94), ear position (p-value = 0.45), cough (p-value = 0.71), temperature (p-value =0.92) and fecal (p value =0.58) between animals of both groups were not statistically significant. The differences in the means regarding the percentage of consumption between the control group and the Ancesol group proved to be significant (p value < 0.001). However, in the case of differences in means relating to ingestion speed (p-value =0.53), average daily gain (p-value = 0.13) and visits without consumption (p-value = 0.65) these were not statistically significant. In view of the results obtained, this study did not provide favorable indications regarding the use of this antihistamine in the treatment of bovine respiratory disease; however, it would be advantageous to carry out studies with a larger population and covering more than one farm
ABSTRACT - CLINICAL STUDY ON THE USE OF ANTIHISTAMINE IN BOVINE RESPIRATORY DISEASE - Bovine respiratory disease is a common condition in dairy calves and, despite efforts to contest it, its treatment continues to present challenges. It is essential to identify possible improvements in this process to increase its effectiveness. The main objective of this trial was to evaluate the effectiveness of using an antihistamine, chlorphenamine maleate (Ancesol®) in the treatment of bovine respiratory disease, using clinical scoring systems to evaluate the clinical signs most associated with this disease, and use of records from automated milk feeders, to evaluate dietary indicators percentage of consumption, speed of ingestion, average daily gain and visits without consumption. For the present study, 60 dairy calves were evaluated, aged between 7 and 88 days, belonging to a single dairy farm, located in the Benavente area. The calves, diagnosed with respiratory disease, were randomly distributed into two groups, the control group (n=31) and the Ancesol group (n=29). All calves were evaluated for three days after diagnosis, and clinical scores of the following clinical signs were recorded: nasal discharge, ocular discharge, ear position, cough, rectal temperature and stool consistency. The dietary indicators, percentage of consumption, speed of ingestion, average daily gain and visits without consumption, were obtained through the automated milk feeders, during the period of 5 days before the diagnosis of bovine respiratory disease and 15 days after the diagnosis. The differences in means relative to clinical scores: nasal discharge (p-value = 0.94), ear position (p-value = 0.45), cough (p-value = 0.71), temperature (p-value =0.92) and fecal (p value =0.58) between animals of both groups were not statistically significant. The differences in the means regarding the percentage of consumption between the control group and the Ancesol group proved to be significant (p value < 0.001). However, in the case of differences in means relating to ingestion speed (p-value =0.53), average daily gain (p-value = 0.13) and visits without consumption (p-value = 0.65) these were not statistically significant. In view of the results obtained, this study did not provide favorable indications regarding the use of this antihistamine in the treatment of bovine respiratory disease; however, it would be advantageous to carry out studies with a larger population and covering more than one farm
Descrição
Dissertação de Mestrado Integrado em Medicina Veterinária, área científica de Clínica
Palavras-chave
Doença respiratória bovina Anti-histamínico Sistema de pontuação clínico Amamentadoras automáticas Bovine respiratory disease Antihistamine Clinical scoring system Automated milk feeders
Contexto Educativo
Citação
Silva BGT. 2025. Estudo clínico de utilização de anti-histamínico na doença respiratória bovina [dissertação de mestrado]. Lisboa: FMV-Universidade de Lisboa
Editora
Universidade de Lisboa, Faculdade de Medicina Veterinária