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Pickering Emulsions Stabilized by Calcium Carbonate Particles: A New Topical Formulation

2020-07-31Journal article Open access
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dc.contributor.authorMarto, Joana
dc.contributor.authorNunes, Andreia
dc.contributor.authorMartins, Ana Margarida
dc.contributor.authorCarvalheira, João
dc.contributor.authorPrazeres, Pedro
dc.contributor.authorGonçalves, Lídia
dc.contributor.authorMarques, Alexandre
dc.contributor.authorLucas, António
dc.contributor.authorRibeiro, Helena Margarida
dc.date.accessioned2024-01-19T19:11:04Z
dc.date.available2024-01-19T19:11:04Z
dc.date.issued2020-07-31
dc.date.updated2023-02-27T18:44:12Z
dc.description© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).pt_PT
dc.description.abstractPickering emulsions are systems composed of two immiscible fluids stabilized by solid organic or inorganic particles. Pickering emulsions are particularly useful in cosmetics, where the surfactants are unwanted, as well as in the pharmaceutical field, where transdermal and/or dermal drug delivery is difficult to achieve and controlled drug release is desired. Here, we studied calcium carbonate particles as stabilizers of Pickering emulsions for topical use. An optimized formulation was obtained using a Quality by Design approach. First, a screening experiment was performed to identify the formulation and process critical variables that affect the quality properties of the Pickering emulsion. The optimization of the production was then studied by establishing the design space. The final formulation was hereinafter investigated regarding the pH, rheological properties, and in vitro cytotoxicity assays. The results showed the formulation had a pH compatible with human skin and a shear thinning behavior. Moreover, this formulation showed a strong network structure, with a suitable spreadability on the skin, allowing an easy application. The in vitro assays were performed to assess the potential cytotoxicity of the calcium carbonate-stabilized emulsion and the particles themselves, and the results revealed that the formulation did not significantly affect the cell viability. In conclusion, the use of calcium carbonate particles as a stabilizer ingredient contributed to achieve an eco-friendly Pickering emulsion.pt_PT
dc.description.sponsorshipThis research was funded by Fundação para a Ciência e a Tecnologia, Portugal (UID/DTP/04138/2019, PTDC/MEC-DER/30198/2017, and CEECINST/00145/2018) and by Carbomin.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMarto J, Nunes A, Martins AM, Carvalheira J, Prazeres P, Gonçalves L, et al. Pickering emulsions stabilized by calcium carbonate particles: a new topical formulation. Cosmetics [Internet]. 31 de julho de 2020;7(3):62. Disponível em: https://www.mdpi.com/2079-9284/7/3/62pt_PT
dc.identifier.doi10.3390/cosmetics7030062pt_PT
dc.identifier.issn2079-9284
dc.identifier.slugcv-prod-2118924
dc.identifier.urihttp://hdl.handle.net/10451/61998
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationCEECINST/00145/2018pt_PT
dc.relationResearch Institute for Medicines
dc.relation.publisherversionhttps://www.mdpi.com/2079-9284/7/3/62pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectcalcium carbonatept_PT
dc.subjectPickering emulsionspt_PT
dc.subjectQuality by Designpt_PT
dc.subjectemulsion stabilizerpt_PT
dc.subjecteco-friendly cosmeticspt_PT
dc.titlePickering Emulsions Stabilized by Calcium Carbonate Particles: A New Topical Formulationpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleResearch Institute for Medicines
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FDTP%2F04138%2F2019/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/Concurso para Financiamento de Projetos de Investigação Científica e Desenvolvimento Tecnológico em Todos os Domínios Científicos - 2017/PTDC%2FMEC-DER%2F30198%2F2017/PT
oaire.citation.issue3pt_PT
oaire.citation.startPage62pt_PT
oaire.citation.titleCosmeticspt_PT
oaire.citation.volume7pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamConcurso para Financiamento de Projetos de Investigação Científica e Desenvolvimento Tecnológico em Todos os Domínios Científicos - 2017
person.familyNameMarques Marto
person.familyNameDiogo Gonçalves
person.familyNameRibeiro
person.givenNameJoana
person.givenNameLídia Maria
person.givenNameHelena
person.identifier1570599
person.identifier.ciencia-id891B-12E1-C2BF
person.identifier.ciencia-id7211-22BA-86AD
person.identifier.ciencia-id161F-B79B-D660
person.identifier.orcid0000-0001-5523-5622
person.identifier.orcid0000-0002-6799-2740
person.identifier.orcid0000-0002-2429-7991
person.identifier.ridE-2944-2015
person.identifier.scopus-author-id35896704400
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.cv.cienciaid7211-22BA-86AD | Lídia Maria Diogo Gonçalves
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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