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Pickering Emulsions Stabilized by Calcium Carbonate Particles: A New Topical Formulation
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Orientador(es)
Resumo(s)
Pickering emulsions are systems composed of two immiscible fluids stabilized by solid organic or inorganic particles. Pickering emulsions are particularly useful in cosmetics, where the surfactants are unwanted, as well as in the pharmaceutical field, where transdermal and/or dermal drug delivery is difficult to achieve and controlled drug release is desired. Here, we studied calcium carbonate particles as stabilizers of Pickering emulsions for topical use. An optimized formulation was obtained using a Quality by Design approach. First, a screening experiment was performed to identify the formulation and process critical variables that affect the quality properties of the Pickering emulsion. The optimization of the production was then studied by establishing the design space. The final formulation was hereinafter investigated regarding the pH, rheological properties, and in vitro cytotoxicity assays. The results showed the formulation had a pH compatible with human skin and a shear thinning behavior. Moreover, this formulation showed a strong network structure, with a suitable spreadability on the skin, allowing an easy application. The in vitro assays were performed to assess the potential cytotoxicity of the calcium carbonate-stabilized emulsion and the particles themselves, and the results revealed that the formulation did not significantly affect the cell viability. In conclusion, the use of calcium carbonate particles as a stabilizer ingredient contributed to achieve an eco-friendly Pickering emulsion.
Descrição
© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Palavras-chave
calcium carbonate Pickering emulsions Quality by Design emulsion stabilizer eco-friendly cosmetics
Contexto Educativo
Citação
Marto J, Nunes A, Martins AM, Carvalheira J, Prazeres P, Gonçalves L, et al. Pickering emulsions stabilized by calcium carbonate particles: a new topical formulation. Cosmetics [Internet]. 31 de julho de 2020;7(3):62. Disponível em: https://www.mdpi.com/2079-9284/7/3/62
Editora
MDPI