A carregar...
Publicação
Potencial terapêutico das células estaminais do cordão umbilical
| Nome: | Descrição: | Tamanho: | Formato: | |
|---|---|---|---|---|
| 1.15 MB | Adobe PDF |
Autores
Orientador(es)
Resumo(s)
Na década de 80 demonstrou-se, pela primeira vez, que o cordão umbilical é uma fonte relevante de células hematopoiéticas transplantáveis. A partir daí, é considerado um importante reservatório de células, com potencial terapêutico para muitas situações clínicas. Embora o sangue do cordão umbilical seja utilizado essencialmente em doenças hematológicas, o espetro de patologias para as quais fornece terapia efetiva foi expandido de forma significativa, incluindo também condições não hematológicas.
O cordão umbilical é utilizado como fonte de terapia celular regenerativa e modulação imunológica. A colheita e criopreservação de células derivadas do cordão umbilical tornaram-se, assim, uma opção frequente. No entanto, levantam-se questões sobre o custo versus os benefícios dos bancos de células estaminais e, também, questões éticas e jurídicas complexas.
Esta monografia estuda questões relacionadas com a conservação de células derivadas do sangue e tecido do cordão umbilical e o grande potencial de aplicações clínicas atuais. Em particular, descrevem-se as questões práticas inerentes à colheita, processamento e conservação a longo prazo das células recolhidas do cordão umbilical, aos diferentes tipos de células estaminais existentes e suas atuais e potencias aplicações clínicas. Torna-se, assim, evidente a tendência crescente de utilização destas células estaminais em cuidados de saúde em todo o mundo.
In the 1980s it was found evidence that the umbilical cord is a relevant source of transplantable hematopoietic cells. Since then, it is now considered the most abundant reservoir of cells with therapeutic potential for many clinical cases. Although umbilical cord blood is used primarily in haematological diseases the spectrum of pathologies for which it provides effective therapy has been significantly expanded including non-haematological conditions. Umbilical cord is used today as a source of regenerative cellular therapy and immune modulation. Harvesting and cryopreservation of umbilical cord-derived cells have thus become a frequent option. However, questions have been raised on the cost versus the benefits of stem cell banks and some complex ethical and legal issues are being discussed. This monography examines the preservation of blood-derived cells and umbilical cord tissue and the great potential of its current clinical applications. It examines the practical issues of long-term collection, processing and conservation of umbilical cord harvested cells and describes the different types of existing stem cells and their current and potential clinical applications. It concludes that it is possible to see an increasing trend on the use of stem cells in health care around the world.
In the 1980s it was found evidence that the umbilical cord is a relevant source of transplantable hematopoietic cells. Since then, it is now considered the most abundant reservoir of cells with therapeutic potential for many clinical cases. Although umbilical cord blood is used primarily in haematological diseases the spectrum of pathologies for which it provides effective therapy has been significantly expanded including non-haematological conditions. Umbilical cord is used today as a source of regenerative cellular therapy and immune modulation. Harvesting and cryopreservation of umbilical cord-derived cells have thus become a frequent option. However, questions have been raised on the cost versus the benefits of stem cell banks and some complex ethical and legal issues are being discussed. This monography examines the preservation of blood-derived cells and umbilical cord tissue and the great potential of its current clinical applications. It examines the practical issues of long-term collection, processing and conservation of umbilical cord harvested cells and describes the different types of existing stem cells and their current and potential clinical applications. It concludes that it is possible to see an increasing trend on the use of stem cells in health care around the world.
Descrição
Trabalho Final de Mestrado Integrado, Ciências Farmacêuticas, Universidade de Lisboa, Faculdade de Farmácia, 2017
Palavras-chave
Cordão umbilical Células estaminais Criopreservação Bancos de células Aplicações terapêuticas Mestrado Integrado - 2017