Implementation of a Functional Semantic Similarity Measure between Gene-Products

Couto, Francisco M.; Silva, Mário J.; Coutinho, Pedro M.

http://hdl.handle.net/10451/14233

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Authors

Couto, Francisco M.

Silva, Mário J.

Coutinho, Pedro M.

Abstract(s)

Sequence similarity is a common technique to compare gene-products. However, many applications need to compare gene-products based on what they do, not how they are. Most gene-products are being annotated with terms describing their biological function. These terms are defined in biological ontologies. This makes it possible to implement similarity measures between gene-products based on their behavior. We define FuSSiMeG, a functional similarity measure between gene-products that compares the semantic similarity between the terms in their annotations. Software available from http://xldb.fc.ul.pt/rebil/ssm/