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New insights into the role of epithelial–mesenchymal transition during aging

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dc.contributor.authorSantos, Francisco
dc.contributor.authorMoreira, Cristiana
dc.contributor.authorNobrega-Pereira, Sandrina
dc.contributor.authorJesus, Bruno Bernardes De
dc.date.accessioned2022-08-24T13:37:30Z
dc.date.available2022-08-24T13:37:30Z
dc.date.issued2019
dc.description© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).pt_PT
dc.description.abstractEpithelial⁻mesenchymal transition (EMT) is a cellular process by which differentiated epithelial cells undergo a phenotypic conversion to a mesenchymal nature. The EMT has been increasingly recognized as an essential process for tissue fibrogenesis during disease and normal aging. Higher levels of EMT proteins in aged tissues support the involvement of EMT as a possible cause and/or consequence of the aging process. Here, we will highlight the existing understanding of EMT supporting the phenotypical alterations that occur during normal aging or pathogenesis, covering the impact of EMT deregulation in tissue homeostasis and stem cell function.pt_PT
dc.description.sponsorshipThis work was supported by Fundação para a Ciência e Tecnologia (FCT) (PTDC/BIM-MED/0032/2014). S.N.-P. has a FCT contract.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationInt J Mol Sci. 2019 Feb 19;20(4):891pt_PT
dc.identifier.doi10.3390/ijms20040891pt_PT
dc.identifier.eissn1422-0067
dc.identifier.issn1661-6596
dc.identifier.urihttp://hdl.handle.net/10451/54184
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relation.publisherversionhttps://www.mdpi.com/journal/ijmspt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectEMTpt_PT
dc.subjectAgingpt_PT
dc.subjectCellular reprogrammingpt_PT
dc.subjectEpithelial–mesenchymal transitionpt_PT
dc.subjectFibrosispt_PT
dc.titleNew insights into the role of epithelial–mesenchymal transition during agingpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardNumberPTDC/BIM-MED/0032/2014
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FBIM-MED%2F0032%2F2014/PT
oaire.citation.issue4pt_PT
oaire.citation.titleInternational Journal of Molecular Sciencespt_PT
oaire.citation.volume20pt_PT
oaire.fundingStream3599-PPCDT
person.familyNameNobrega-Pereira
person.familyNameBernardes de Jesus
person.givenNameSandrina
person.givenNameBruno
person.identifier.ciencia-idA211-DF5C-7A77
person.identifier.ciencia-idAB1E-11CF-D3A5
person.identifier.orcid0000-0002-9652-1382
person.identifier.orcid0000-0002-6407-3466
person.identifier.scopus-author-id24766504900
person.identifier.scopus-author-id36730641700
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublication1c0c898a-931d-420c-b48c-82b019a4834e
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