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Publicação
New insights into the role of epithelial–mesenchymal transition during aging
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Orientador(es)
Resumo(s)
Epithelial⁻mesenchymal transition (EMT) is a cellular process by which differentiated epithelial cells undergo a phenotypic conversion to a mesenchymal nature. The EMT has been increasingly recognized as an essential process for tissue fibrogenesis during disease and normal aging. Higher levels of EMT proteins in aged tissues support the involvement of EMT as a possible cause and/or consequence of the aging process. Here, we will highlight the existing understanding of EMT supporting the phenotypical alterations that occur during normal aging or pathogenesis, covering the impact of EMT deregulation in tissue homeostasis and stem cell function.
Descrição
© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Palavras-chave
EMT Aging Cellular reprogramming Epithelial–mesenchymal transition Fibrosis
Contexto Educativo
Citação
Int J Mol Sci. 2019 Feb 19;20(4):891
Editora
MDPI