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Publicação
Exossomas : veículos de comunicação celular em doenças do Sistema Nervoso Central e alvos terapêuticos
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Resumo(s)
Exosomes are extracellular vesicles shed by cells through a process that involves fusion of multivesicular bodies with the plasma membrane, usually having around 30 a 100 nm of diameter. Exosomes have been found to contain multiple biological molecules, of which we can mention several proteins who serve multiple functions, lipids in higher concentrations than the mother-cell of the exosome, and RNA's that are capable of transferring genetic material from one cell to another. These molecules allow for exo- somes to exert a myriad of biological and pathological by acting as a means of cell com- munication. In the Central Nervous System, exossomes play an important role in the development of neurons and glial cells, and take partin the normal physiology of the brain, with the most flagrant case being oligodendrocyte-neuron communication. In pathological brain conditions, exosomes were found to play an important role in the transmission of diseases in the brain and many pathological substances were found to be transmitted from diseased cells to healthy ones, creating specific pathological exos- somes. At the same time, this opens up opportunities in the medical field of exploring exossomes as non-invasive biomarkers of nervous system disease, and as potential ther- apeutic agents. Keywords:
Descrição
Trabalho Final de Mestrado Integrado, Ciências Farmacêuticas, Universidade de Lisboa, Faculdade de Farmácia, 2015
Palavras-chave
Mestrado Integrado - 2015