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Effect of chlorhexidine incorporation on acrylic reline resins : release studies
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Resumo(s)
The use of drug carriers and controlled-release agents are a promising strategy to treat denture stomatitis, since it has been claimed that they maintain ideal therapeutic levels of the drug at the site of infection. Chlorhexidine incorporation into denture acrylic resins has shown good results, both on releasing and microbiological tests. The main purpose of this study is to evaluate the release of chlorhexidine from acrylic reline resins, specifically the effect of different materials composition and drug loading on the drug release, with artificial saliva as media solution. Three different materials were evaluated in the present study, Kooliner, Ufi Gel Hard and Probase Cold. For each one, one control group and five experimental groups, incorporated with chlorhexidine 1%, 2.5%, 5%, 7.5% and 10% (w/w), were produced. A total of 54 cylinder-shaped specimens were evaluated. The cylinders were stored individually in graduated falcon tubes and covered with saliva at pH=7. The falcons were then placed into an incubator and, at specific time intervals, an aliquot were collected from each falcon and the same amount of artificial saliva was renovated, in order to simulate the constant salivary renovation. The samples were analyzed by UVspectroscopy and the chlorhexidine content was determined. The results showed that a high initial release was followed by a slower and steadier elution, during the entire study period. Besides it was demonstrated that the greatest amount of chlorhexidine release occurred within the first 24-48h of incubation, the results also showed that the release of chlorhexidine is affected by different materials composition, since that, for all chlorhexidine %, Ufi Gel Hard released the highest amount of chlorhexidine. It was also established that the release of chlorhexidine is drug loading-dependant. In addition, it was shown that the maximum cumulative release was 1.77%, so only a small amount of initial loaded chlorhexidine is liberated. However, all the materials, even with lower chlorhexidine % (1% w/w), presented a cumulative concentration of chlorhexidine superior than its MIC values. Overall, the results indicate that chlorhexidine delivery systems based on acrylic reline resins are a potential approach in the treatment of denture stomatitis.
Descrição
Tese de mestrado, Medicina Dentária, Universidade de Lisboa, Faculdade de Medicina Dentária, 2015
Palavras-chave
Prótese Doenças da mucosa oral Candidiase Estomatites Teses de mestrado - 2015