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Publicação
Contribution of FoxP3+ Tfr cells to overall human blood CXCR5+ T cells
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Autores
Orientador(es)
Resumo(s)
The identification that T follicular helper (Tfh) cells is critical for the emergence of germinal centre responses prompted the study of CXCR5-expressing CD4+ T cell subsets in autoimmunity. However, circulating CXCR5-expressing T cells are heterogeneous by containing Forkhead box protein 3 (FoxP3)+ T follicular regulatory (Tfr) cells in addition to bona fide Tfh cells. Such heterogeneity may hamper the analysis of the contribution of specific follicular T cell subsets for autoimmune pathogenesis. Therefore, separate assessment of Tfh and Tfr populations offer greater opportunities for stratification of autoimmune patients, such as Sjögren's syndrome patients.
Descrição
© 2019 British Society for Immunology. This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model)
Palavras-chave
Foxp3 Sjögren’s syndrome T follicular helper cells T follicular regulatory cells
Contexto Educativo
Citação
Clin Exp Immunol. 2019 Mar;195(3):302-304
Editora
Oxford University Press