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The challenge of peptide proteolytic stability studies: scarce data, difficult readability, and the need for harmonization

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dc.contributor.authorCavaco, Marco
dc.contributor.authorAndreu, David
dc.contributor.authorCastanho, Miguel A. R. B.
dc.date.accessioned2023-05-10T10:39:36Z
dc.date.available2023-05-10T10:39:36Z
dc.date.issued2020
dc.description© 2020 Wiley-VCH GmbHpt_PT
dc.description.abstractProteolytic stability assessment is increasingly viewed as a fundamental component of peptide characterization, arguably of comparable importance as efficacy and toxicity data. A literature survey over the last decade reveals steady growth in the stability information available. However, it also uncovers two significant problems that hinder proper data comparison: 1) the use of different stability assays, and 2) the differences in how stability information is reported. In this Viewpoint, we present results from a database meta-analysis as well as concerns about the stability assessments published so far. We also suggest guidelines for a proper discussion between experts in the field on how to improve data readability so that peptide stability, an often-missing parameter in older literature, is adequately reported to take maximum advantage of it.pt_PT
dc.description.sponsorshipWe thank the Portuguese Fundação para a Ciência e a Tecnologia (FCT, grants PD/BD/128281/2017, PTDC/BBB-NAN/1578/2014, PTDC/BIA-VIR/29495/2017, UID/Multi/04349/2019 and PTDC/QUI-NUC/30147/2017), the Spanish Ministry of Economy and Innovation (MINECO, grants AGL2014-52395-C2-2-R, AGL2017-84097-C2-2-R, and Maria de Maeztu Program for Centers of Excellence); the European Union H2020-MSCA-RISE-2014 program (grant no. 828774), and the „La Caixa“ Banking Foundation (grant HR17-00409) for financial support.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationAngew. Chem. 2021, 133, 1710-1712pt_PT
dc.identifier.doi10.1002/ange.202006372pt_PT
dc.identifier.doi10.1002/anie.202006372pt_PT
dc.identifier.issn0044-8249
dc.identifier.issn1521-3757
dc.identifier.urihttp://hdl.handle.net/10451/57398
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWileypt_PT
dc.relationTrans-BBB peptides for targeting brain metastasis
dc.relationCentre for Nuclear Sciences and Technologies
dc.relationTargeting the transporters of cationic amino acids for cancer radiotheranostics: experimental and computational chemistry approach
dc.relation''One size fits all'' unique drug to eradicate multiple viral species simultaneously from the central nervous system of co-infected individuals
dc.relation.publisherversionhttps://onlinelibrary.wiley.com/journal/15213757pt_PT
dc.subjectDegradationpt_PT
dc.subjectPeptidespt_PT
dc.subjectProteolysispt_PT
dc.subjectStabilitypt_PT
dc.titleThe challenge of peptide proteolytic stability studies: scarce data, difficult readability, and the need for harmonizationpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleTrans-BBB peptides for targeting brain metastasis
oaire.awardTitleCentre for Nuclear Sciences and Technologies
oaire.awardTitleTargeting the transporters of cationic amino acids for cancer radiotheranostics: experimental and computational chemistry approach
oaire.awardTitle''One size fits all'' unique drug to eradicate multiple viral species simultaneously from the central nervous system of co-infected individuals
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//PD%2FBD%2F128281%2F2017/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FBBB-NAN%2F1578%2F2014/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FBIA-VIR%2F29495%2F2017/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FMulti%2F04349%2F2019/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FQUI-NUC%2F30147%2F2017/PT
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/828774/EU
oaire.citation.endPage1712pt_PT
oaire.citation.issue4pt_PT
oaire.citation.startPage1710pt_PT
oaire.citation.titleAngewandte Chemiept_PT
oaire.citation.volume133pt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStream3599-PPCDT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream3599-PPCDT
oaire.fundingStreamH2020
person.familyNameCavaco
person.familyNameCastanho
person.givenNameMarco
person.givenNameMiguel
person.identifier1069324
person.identifier.ciencia-id1412-63B8-7494
person.identifier.orcid0000-0002-0938-9038
person.identifier.orcid0000-0001-7891-7562
person.identifier.scopus-author-id56605575600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameEuropean Commission
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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