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Inhibition of enzymes important for Alzheimer’s disease by antioxidant extracts prepared from 15 New Zealand medicinal trees and bushes

2020Journal article Open access
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dc.contributor.authorMajid, Hafiz
dc.contributor.authorSilva, Filipa V.M.
dc.date.accessioned2021-09-27T09:11:43Z
dc.date.available2021-09-27T09:11:43Z
dc.date.issued2020
dc.description.abstractAlzheimer’s disease is characterised by progressive mental deterioration, related to ageing and senility. Thirty methanol and ethyl acetate extracts from 15 native New Zealand trees and bushes were produced and tested for the inhibition of three enzymes related to neurotransmission: acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and beta-secretase (BACE). In addition the IC50 for the antioxidant potential of the extracts was determined. Weinmannia racemosa and Kunzea ericoides were effective inhibitors of AChE-BChE and beta-secretase, respectively. The IC50 for W. racemosa extracts against AChE and BChE ranged between 8.09 μg/mL and 37.07 μg/mL. The ethyl acetate extract of Schefflera digitata was also an effective inhibitor of BChE (IC50 = 25.38 μg/mL). K. ericoides IC50 for beta-secretase were 29.05 μg/mL and 36.40 μg/ml. The highest radical scavenging activity (RSA) was detected in the methanol extract of Aristotelia serrata (IC50 = 2.34 μg/mL), followed by both extracts of Hebe stricta and W. racemosa, and last the methanol extracts of K. ericoides and Pomaderris kumeraho, which presented higher RSA than the reference antioxidant (IC50 <12.0 μg/mL). W. racemosa showed inhibitory activity against AChE and BChE enzymes and antioxidant activity, which suggests these extracts may have potential for application in patients suffering from Alzheimer’s disease and other dementiaspt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationHafiz Majid & Filipa V. M. Silva (2020) Inhibition of enzymes important for Alzheimer’s disease by antioxidant extracts prepared from 15 New Zealand medicinal trees and bushes, Journal of the Royal Society of New Zealand, 50:4, 538-551pt_PT
dc.identifier.doi10.1080/03036758.2020.1741403pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.5/22011
dc.language.isoengpt_PT
dc.publisherTaylor & Francispt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectbioactivept_PT
dc.subjectacetylcholinesterasept_PT
dc.subjectbutyrylcholinesterasept_PT
dc.subjectbetasecretasept_PT
dc.subjectradical scavenging activitypt_PT
dc.subjectdementiapt_PT
dc.titleInhibition of enzymes important for Alzheimer’s disease by antioxidant extracts prepared from 15 New Zealand medicinal trees and bushespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleJournal of the Royal Society of New Zealandpt_PT
person.familyNameVinagre Marques da Silva Oliveira
person.givenNameMaria Filipa
person.identifier.ciencia-idB610-66DA-A3AC
person.identifier.orcid0000-0003-4700-2938
person.identifier.scopus-author-id22942414000
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationc6da545d-92cd-4bee-9e4e-6a0afc4e71cd
relation.isAuthorOfPublication.latestForDiscoveryc6da545d-92cd-4bee-9e4e-6a0afc4e71cd

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