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Authors
Advisor(s)
Abstract(s)
Alzheimer’s disease is characterised by progressive mental
deterioration, related to ageing and senility. Thirty methanol and
ethyl acetate extracts from 15 native New Zealand trees and
bushes were produced and tested for the inhibition of three
enzymes related to neurotransmission: acetylcholinesterase
(AChE), butyrylcholinesterase (BChE) and beta-secretase (BACE). In
addition the IC50 for the antioxidant potential of the extracts was
determined. Weinmannia racemosa and Kunzea ericoides were
effective inhibitors of AChE-BChE and beta-secretase, respectively.
The IC50 for W. racemosa extracts against AChE and BChE ranged
between 8.09 μg/mL and 37.07 μg/mL. The ethyl acetate extract
of Schefflera digitata was also an effective inhibitor of BChE (IC50 =
25.38 μg/mL). K. ericoides IC50 for beta-secretase were 29.05 μg/mL
and 36.40 μg/ml. The highest radical scavenging activity (RSA) was
detected in the methanol extract of Aristotelia serrata (IC50 =
2.34 μg/mL), followed by both extracts of Hebe stricta and
W. racemosa, and last the methanol extracts of K. ericoides and
Pomaderris kumeraho, which presented higher RSA than the
reference antioxidant (IC50 <12.0 μg/mL). W. racemosa showed
inhibitory activity against AChE and BChE enzymes and
antioxidant activity, which suggests these extracts may have
potential for application in patients suffering from Alzheimer’s
disease and other dementias
Description
Keywords
bioactive acetylcholinesterase butyrylcholinesterase betasecretase radical scavenging activity dementia
Pedagogical Context
Citation
Hafiz Majid & Filipa V. M. Silva (2020) Inhibition of enzymes important for Alzheimer’s disease by antioxidant extracts prepared from 15 New Zealand medicinal trees and bushes, Journal of the Royal Society of New Zealand, 50:4, 538-551
Publisher
Taylor & Francis