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Orchestrating mitochondria in neurons: Cytoskeleton as the conductor

2020Journal article Open access
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dc.contributor.authorCardanho-Ramos, Carlos
dc.contributor.authorFaria-Pereira, Andreia
dc.contributor.authorMorais, Vanessa A.
dc.date.accessioned2021-09-21T15:29:14Z
dc.date.available2021-09-21T15:29:14Z
dc.date.issued2020
dc.description© 2019 The Authors. Cytoskeleton published by Wiley Periodicals, Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.pt_PT
dc.description.abstractMitochondria are crucial to support synaptic activity, particularly through ATP production and Ca2+ homeostasis. This implies that mitochondria need to be well distributed throughout the different neuronal sub-compartments. To achieve this, a tight and precise regulation of several neuronal cytoskeleton players is necessary to transport and dock mitochondria. As post-mitotic cells, neurons are highly dependent on mitochondrial quality control mechanisms and several cytoskeleton proteins have been implicated in mitophagy. Therefore, all of these processes are orchestrated by the crosstalk between mitochondria and the neuronal cytoskeleton to form a coordinated and tuned symphony.pt_PT
dc.description.sponsorshipThe authors are supported by Fundação para a Ciência e Tecnologia, Grant references for CCRPD/BD/135521/2018, AFP PD/BD/114113/2015, VAM IF/01693/2014, Funding reference: UID/BIM/50005/2019, project funded by Fundação para a Ciência e a Tecnologia (FCT)/Ministério da Ciência, Tecnologia e Ensino Superior (MCTES) through Fundos do Orçamento de Estado; by European Research Council, grant ERC-StG-679168; and European Molecular Biology Organization, grant EMBO-IG/3309.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationCytoskeleton (Hoboken). 2020 Mar;77(3-4):65-75pt_PT
dc.identifier.doi10.1002/cm.21585pt_PT
dc.identifier.eissn1949-3592
dc.identifier.issn1949-3584
dc.identifier.urihttp://hdl.handle.net/10451/49563
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherJohn Wiley & Sons, Inc.pt_PT
dc.relationIF/01693/2014pt_PT
dc.relationEMBO-IG/3309pt_PT
dc.relationQuality Control and Maintenance of Synaptic Mitochondria
dc.relation.publisherversionhttps://onlinelibrary.wiley.com/journal/19493592pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectDockingpt_PT
dc.subjectMitochondriapt_PT
dc.subjectNeuronal cytoskeletonpt_PT
dc.subjectSynapsept_PT
dc.subjectTransportpt_PT
dc.titleOrchestrating mitochondria in neurons: Cytoskeleton as the conductorpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleQuality Control and Maintenance of Synaptic Mitochondria
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/OE/70670/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/OE/54018/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/154779/PT
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/679168/EU
oaire.citation.endPage75pt_PT
oaire.citation.issue3-4pt_PT
oaire.citation.startPage65pt_PT
oaire.citation.titleCytoskeletonpt_PT
oaire.citation.volume77pt_PT
oaire.fundingStreamOE
oaire.fundingStreamOE
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamH2020
person.familyNameCardanho-Ramos
person.familyNameMorais
person.givenNameCarlos
person.givenNameVanessa
person.identifier.orcid0000-0001-6178-1654
person.identifier.orcid0000-0002-0830-0548
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameEuropean Commission
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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