Orchestrating mitochondria in neurons: Cytoskeleton as the conductor

Cardanho-Ramos, Carlos; Faria-Pereira, Andreia; Morais, Vanessa A.

http://hdl.handle.net/10451/49563

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Autores

Cardanho-Ramos, Carlos

Faria-Pereira, Andreia

Morais, Vanessa A.

Resumo(s)

Mitochondria are crucial to support synaptic activity, particularly through ATP production and Ca2+ homeostasis. This implies that mitochondria need to be well distributed throughout the different neuronal sub-compartments. To achieve this, a tight and precise regulation of several neuronal cytoskeleton players is necessary to transport and dock mitochondria. As post-mitotic cells, neurons are highly dependent on mitochondrial quality control mechanisms and several cytoskeleton proteins have been implicated in mitophagy. Therefore, all of these processes are orchestrated by the crosstalk between mitochondria and the neuronal cytoskeleton to form a coordinated and tuned symphony.

Descrição

© 2019 The Authors. Cytoskeleton published by Wiley Periodicals, Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.