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Advisor(s)
Abstract(s)
Agentes antifúngicos são fármacos amplamente utilizados contra diversos patógenos. Estes são incluídos em tratamentos de infeções tanto sistémicas como localizadas, assim como em profilaxia destas infeções, especialmente em doentes imunocomprometidos.
O sucesso destas terapêuticas está dependente da eficácia da dose administrada e da concentração do agente no organismo, estando esta associada à segurança e à possível toxicidade que advém da administração deste tipo de agentes. Desta forma é possível recorrer à TDM para realizar a medição das concentrações séricas de antifúngicos e desta forma avaliar a necessidade de alterar ou não a dose administrada de modo a reduzir potenciais efeitos adversos e minimizar o aparecimento de resistências.
Este trabalho reúne informação sobre diferentes terapêuticas com antifúngicos azóis e a possível aplicação de TDM para avaliação das mesmas em diferentes populações.
Antifungal agents are drugs widely used against several pathogens. These are included in treatments for both systemic and localized infections, as well as in prophylaxis of these infections, especially in immunocompromised patients. The success of these therapies is dependent on the effectiveness of the dose administe-red and the concentration of the agent in the body, which is associated with the safety and possible toxicity that comes from the administration of these types of agents. In this way, it is possible to use TDM to measure serum concentrations of antifungals and thus assess the need to change or not the dose administered in order to reduce potential ad-verse effects and minimize the appearance of resistances. This work gathers information about different therapies with azole antifungals and the possible application of TDM to evaluate them in different populations.
Antifungal agents are drugs widely used against several pathogens. These are included in treatments for both systemic and localized infections, as well as in prophylaxis of these infections, especially in immunocompromised patients. The success of these therapies is dependent on the effectiveness of the dose administe-red and the concentration of the agent in the body, which is associated with the safety and possible toxicity that comes from the administration of these types of agents. In this way, it is possible to use TDM to measure serum concentrations of antifungals and thus assess the need to change or not the dose administered in order to reduce potential ad-verse effects and minimize the appearance of resistances. This work gathers information about different therapies with azole antifungals and the possible application of TDM to evaluate them in different populations.
Description
Trabalho Final de Mestrado Integrado, Ciências Farmacêuticas, 2020, Universidade de Lisboa, Faculdade de Farmácia.
Keywords
Antifúngico Azol TDM Farmacocinética Farmacodinâmica Voriconazol Fluconazol Posaconazol Itraconazol Isavuconazol Mestrado integrado - 2020