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Advisor(s)
Abstract(s)
A via pulmonar é dotada de características únicas que permitem ser uma via de administração local e sistémica de fármacos amplamente aceite.
A otimização de formulações para administração com recurso à via pulmonar tem sido foco de investigação principalmente na área dos transportadores para os inaladores de pó seco. Um equilíbrio otimizado das forças de adesão e coesão garante a estabilidade da formulação, mas também deve permitir a separação da substância ativa do transportador na corrente de ar que se forma depois da inalação, permitindo uma eficiente aerossolização. Muitas estratégias com recurso à engenharia de partículas têm sido desenvolvidas e reportadas. Contudo a lactose continua a ser o transportador mais utilizado nas formulações de inaladores de pó seco pois o seu perfil toxicológico é bem conhecido e apresenta estabilidade e compatibilidade com as substâncias ativas utilizados nestas formas farmacêuticas.
The pulmonary route is endowed with unique characteristics that allow it to be a widely accepted route of local and systemic drug administration. The optimization of formulations for administration using the pulmonary route has been the focus of research, mainly in carriers for dry powder inhalers. An optimal balance of adhesion and cohesion forces ensures the stability of the formulation but must also allow the separation of the active substance from carrier in the air stream that forms after inhalation, allowing for efficient aerosolization. Many strategies using particle engineering have been developed and reported. However, lactose remains the most used carrier in dry powder inhaler formulations because its toxicological profile is well known, and it has stability and compatibility with the active substances used in these pharmaceutical forms.
The pulmonary route is endowed with unique characteristics that allow it to be a widely accepted route of local and systemic drug administration. The optimization of formulations for administration using the pulmonary route has been the focus of research, mainly in carriers for dry powder inhalers. An optimal balance of adhesion and cohesion forces ensures the stability of the formulation but must also allow the separation of the active substance from carrier in the air stream that forms after inhalation, allowing for efficient aerosolization. Many strategies using particle engineering have been developed and reported. However, lactose remains the most used carrier in dry powder inhaler formulations because its toxicological profile is well known, and it has stability and compatibility with the active substances used in these pharmaceutical forms.
Description
Trabalho Final de Mestrado Integrado, Ciências Farmacêuticas, 2022, Universidade de Lisboa, Faculdade de Farmácia.
Keywords
Transportador Lactose Fração de partículas finas Inalador de pó seco Mestrado integrado - 2022