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Potencial da fotobiomodulação no tratamento da doença renal crónica descompensada no gato doméstico
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A Doença Renal Crónica (DRC) afeta cerca de 40% dos gatos com 10 ou mais anos. O diagnóstico inclui a avaliação de parâmetros bioquímicos como a creatinina e a ureia, medição da pressão arterial, ultrassonografia renal e cálculo do Índice de Resistência Renal (IRR). A descompensação da DRC é frequente, devido ao carácter progressivo da doença e da maior suscetibilidade do doente a possíveis fatores agressores, pela disfunção renal associada à própria DRC. O objetivo da presente dissertação foi avaliar o efeito do LASER terapêutico de classe IV, enquanto técnica terapêutica adjuvante na agudização da DRC. Foi realizado um estudo experimental com 58 gatos (N=58) em episódio de agudização de DRC, que apresentavam em fase de estabilização diferentes graus evolutivos da doença (estadio II-IV da IRIS - Sociedade Internacional de Interesse Renal). Foram divididos em dois grupos, consoante a escolha do detentor: um de controlo (GC N=11) e um experimental (GE N=47) e avaliados em dois tempos distintos: T0 (início da admissão) e T1 (4 dias após admissão). Ambos os grupos receberam o mesmo protocolo terapêutico, com a diferença de que o GE foi submetido ao LASER por 4 dias consecutivos. Algumas das limitações associadas passaram pela desigualdade da amostra entre grupos, pelo tempo reduzido do protocolo de LASER e pelos diferentes estadios da DRC entre indivíduos admitidos ao estudo. Os resultados mostraram diferenças estatisticamente significativas entre os grupos nos valores de creatinina (p=0,019), ureia (p<0,001) e IRR (p=0,03), sugerindo um efeito benéfico da fotobiomodulação como terapia adjuvante na DRC descompensada
Chronic Kidney Disease (CKD) affects approximately 40% of cats aged 10 years or older. Diagnosis typically involves the assessment of biochemical parameters such as creatinine and urea, blood pressure measurement, renal ultrasonography, and calculation of the Renal Resistive Index (RRI). CKD decompensation is frequent due to the progressive nature of the disease and the increased susceptibility of patients to potential insults, stemming from renal dysfunction inherent to CKD itself. The aim of the present dissertation was to evaluate the effect of Class IV therapeutic LASER as an adjunctive treatment in episodes of CKD decompensation. An experimental study was conducted on 58 cats (N=58) undergoing CKD flare-ups, presenting at various stabilization stages of the disease (IRIS stages II–IV – International Renal Interest Society). The animals were divided into two groups according to owner consent: a control group (CG, N=11) and an experimental group (EG, N=47), and were evaluated at two distinct time points: T0 (upon admission) and T1 (four days after admission). Both groups received the same therapeutic protocol, except that the EG was also treated with LASER therapy for four consecutive days. Some limitations of this study include the unequal group sizes, the short duration of LASER treatment, and the variability in CKD stage among included individuals. The results revealed statistically significant differences between the groups in creatinine (p=0.019), urea (p<0.001), and RRI (p=0.03) values, suggesting a beneficial effect of photobiomodulation as an adjunct therapy in decompensated CKD
Chronic Kidney Disease (CKD) affects approximately 40% of cats aged 10 years or older. Diagnosis typically involves the assessment of biochemical parameters such as creatinine and urea, blood pressure measurement, renal ultrasonography, and calculation of the Renal Resistive Index (RRI). CKD decompensation is frequent due to the progressive nature of the disease and the increased susceptibility of patients to potential insults, stemming from renal dysfunction inherent to CKD itself. The aim of the present dissertation was to evaluate the effect of Class IV therapeutic LASER as an adjunctive treatment in episodes of CKD decompensation. An experimental study was conducted on 58 cats (N=58) undergoing CKD flare-ups, presenting at various stabilization stages of the disease (IRIS stages II–IV – International Renal Interest Society). The animals were divided into two groups according to owner consent: a control group (CG, N=11) and an experimental group (EG, N=47), and were evaluated at two distinct time points: T0 (upon admission) and T1 (four days after admission). Both groups received the same therapeutic protocol, except that the EG was also treated with LASER therapy for four consecutive days. Some limitations of this study include the unequal group sizes, the short duration of LASER treatment, and the variability in CKD stage among included individuals. The results revealed statistically significant differences between the groups in creatinine (p=0.019), urea (p<0.001), and RRI (p=0.03) values, suggesting a beneficial effect of photobiomodulation as an adjunct therapy in decompensated CKD
Descrição
Dissertação de Mestrado Integrado em Medicina Veterinária, área científica de Clínica
Palavras-chave
Gato Doença Renal Crónica Fotobiomodulação Azotémia Índice de Resistência Renal Cat Chronic Kidney Disease Photobiomodulation Azotemia Renal Resistive Index