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Primaquine–pyrimidine hybrids: synthesis and dual-stage antiplasmodial activity

2015Journal article Restricted access
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dc.contributor.authorKaur, Hardeep
dc.contributor.authorMachado, Marta
dc.contributor.authorde Kock, Carmen
dc.contributor.authorSmith, Peter
dc.contributor.authorChibale, Kelly
dc.contributor.authorPrudêncio, Miguel
dc.contributor.authorSingh, Kamaljit
dc.date.accessioned2022-04-20T16:11:24Z
dc.date.available2022-04-20T16:11:24Z
dc.date.issued2015
dc.description© 2015 Elsevier Masson SAS. All rights reserved.pt_PT
dc.description.abstractA series of novel pyrimidine-primaquine hybrids were synthesized and their effectiveness against the blood and liver stages of malaria parasites was evaluated. The hybrids displayed enhanced liver stage in vitro activity against P. berghei liver stage infection.pt_PT
dc.description.sponsorshipWe gratefully acknowledge financial assistance from CSIR, New Delhi and Fundação para a Ciência e Tecnologia, Portugal (grant PTDC/SAU-MIC/117060/2010 to MP). H.K. thanks CSIR, New Delhi for senior research fellowship (F. No. 09/254 (0195)/2009-EMR-I).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationEur J Med Chem. 2015 Aug 28;101:266-273pt_PT
dc.identifier.doi10.1016/j.ejmech.2015.06.045pt_PT
dc.identifier.eissn1768-3254
dc.identifier.issn0223-5234
dc.identifier.urihttp://hdl.handle.net/10451/52462
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationUtilization of host cell resources by the malaria parasite in the liver
dc.relation.publisherversionhttps://www.sciencedirect.com/journal/european-journal-of-medicinal-chemistrypt_PT
dc.subjectAntiplasmodial agentspt_PT
dc.subjectBlood stage activitypt_PT
dc.subjectHybrid drugspt_PT
dc.subjectLiver stage activitypt_PT
dc.subjectPrimaquinept_PT
dc.subjectPyrimidinept_PT
dc.titlePrimaquine–pyrimidine hybrids: synthesis and dual-stage antiplasmodial activitypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleUtilization of host cell resources by the malaria parasite in the liver
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FSAU-MIC%2F117060%2F2010/PT
oaire.citation.endPage273pt_PT
oaire.citation.startPage266pt_PT
oaire.citation.titleEuropean Journal of Medicinal Chemistrypt_PT
oaire.citation.volume101pt_PT
oaire.fundingStream3599-PPCDT
person.familyNamePrudêncio
person.givenNameMiguel
person.identifierhttps://scholar.google.pt/citations?user=zduN6wsAAAAJ&hl=pt-PT&oi=ao
person.identifier.ciencia-id5511-16ED-48E0
person.identifier.orcid0000-0003-1746-6029
person.identifier.scopus-author-id6603561872
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication80e4e74d-bf34-4a71-8530-cc3280543b65
relation.isAuthorOfPublication.latestForDiscovery80e4e74d-bf34-4a71-8530-cc3280543b65
relation.isProjectOfPublication8729af9d-d073-49fe-b1ba-11bd63ab7a14
relation.isProjectOfPublication.latestForDiscovery8729af9d-d073-49fe-b1ba-11bd63ab7a14

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