A carregar...
Publicação
Primaquine–pyrimidine hybrids: synthesis and dual-stage antiplasmodial activity
| Nome: | Descrição: | Tamanho: | Formato: | |
|---|---|---|---|---|
| 630.44 KB | Adobe PDF |
Orientador(es)
Resumo(s)
A series of novel pyrimidine-primaquine hybrids were synthesized and their effectiveness against the blood and liver stages of malaria parasites was evaluated. The hybrids displayed enhanced liver stage in vitro activity against P. berghei liver stage infection.
Descrição
© 2015 Elsevier Masson SAS. All rights reserved.
Palavras-chave
Antiplasmodial agents Blood stage activity Hybrid drugs Liver stage activity Primaquine Pyrimidine
Contexto Educativo
Citação
Eur J Med Chem. 2015 Aug 28;101:266-273
Editora
Elsevier