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VISTA is a diagnostic biomarker and immunotherapy target of aggressive feline mammary carcinoma subtypes

2021-11-05Journal article Open access
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dc.contributor.authorGameiro, Andreia
dc.contributor.authorNascimento, Catarina
dc.contributor.authorCorreia, Jorge
dc.contributor.authorFerreira, Fernando
dc.date.accessioned2022-02-03T22:09:55Z
dc.date.available2022-02-03T22:09:55Z
dc.date.issued2021-11-05
dc.descriptionResearch Areas: Oncologypt_PT
dc.description.abstractABSTRACT - Feline mammary carcinoma (FMC) is a common neoplasia, showing aggressive clinicopathological features, without viable therapeutic options. The study of tumor microenvironment has gained importance, due to the ability to control tumor progression by regulating the immune response. Considering the lack of knowledge, feline serum VISTA levels from cats with mammary carcinoma were compared with healthy controls, and with serum levels of PD-1/PD-L1, CTLA-4, LAG-3, IL-6, and TNF-α. In parallel, VISTA tumor expression was evaluated in FMC samples. The obtained data revealed that serum VISTA levels were significantly higher in cats presenting HER2-positive (p = 0.0025) or triple-negative subtypes (p = 0.0019), with higher serum levels in luminal A (p = 0.0025) correlated to the presence of metastasis (p = 0.0471). Furthermore, in HER2- positive or triple-negative tumors, correlations were obtained between serum VISTA levels and the serum levels of the above-mentioned molecules. In tumors, VISTA expression revealed a stronger intensity in cancer cells, when compared to TILs (p < 0.0001). Stratifying the samples by subtypes, a higher number of VISTA-positive TILs was observed in the HER2-positive subtype, compared with triple-negative tumors (p = 0.0138). In conclusion, results support the development of therapeutic strategies for HER2-positive and triple-negative FMC subtypes, reinforcing the use of cats as a human oncology model.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationGameiro A, Nascimento C, Correia J, Ferreira F. 2021. VISTA is a diagnostic biomarker and immunotherapy target of aggressive feline mammary carcinoma subtypes. Cancers, 13(21):5559. Doi: 10.3390/cancers13215559pt_PT
dc.identifier.doi10.3390/cancers13215559pt_PT
dc.identifier.eissn2072-6694
dc.identifier.urihttp://hdl.handle.net/10400.5/23380
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherUniversidade de Lisboa, Faculdade de Medicina Veterináriapt_PT
dc.relationCentre for Interdisciplinary Research in Animal Health
dc.relationDeveloping diagnostic tools for feline mammary carcinomas and improving chemotherapy based on HER2 and topoisometase status
dc.relation.publisherversionhttps://www.mdpi.com/2072-6694/13/21/5559pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectFeline mammary carcinomapt_PT
dc.subjectBreast cancerpt_PT
dc.subjectVISTApt_PT
dc.subjectImmune checkpointpt_PT
dc.subjectCancer modelpt_PT
dc.titleVISTA is a diagnostic biomarker and immunotherapy target of aggressive feline mammary carcinoma subtypespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCentre for Interdisciplinary Research in Animal Health
oaire.awardTitleDeveloping diagnostic tools for feline mammary carcinomas and improving chemotherapy based on HER2 and topoisometase status
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FCVT-EPI%2F3638%2F2014/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00276%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F132260%2F2017/PT
oaire.citation.conferencePlaceBasel, Switzerlandpt_PT
oaire.citation.titleCancerspt_PT
oaire.citation.volumeVol.13(21):5559pt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStream6817 - DCRRNI ID
person.familyNameGameiro
person.familyNameGaspar do Nascimento
person.familyNameFerreira
person.givenNameAndreia
person.givenNameAna Catarina
person.givenNameFernando António da Costa
person.identifier.ciencia-idB718-5199-AA36
person.identifier.ciencia-idF81F-D7D4-57C5
person.identifier.orcid0000-0002-1602-3552
person.identifier.orcid0000-0001-5765-576X
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublicatione35637f2-a72d-4480-9b4c-950509284cc2
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