Loading...
Publication
VISTA is a diagnostic biomarker and immunotherapy target of aggressive feline mammary carcinoma subtypes
| Name: | Description: | Size: | Format: | |
|---|---|---|---|---|
| 3.9 MB | Adobe PDF |
Advisor(s)
Abstract(s)
ABSTRACT - Feline mammary carcinoma (FMC) is a common neoplasia, showing aggressive clinicopathological features, without viable therapeutic options. The study of tumor microenvironment
has gained importance, due to the ability to control tumor progression by regulating the immune
response. Considering the lack of knowledge, feline serum VISTA levels from cats with mammary
carcinoma were compared with healthy controls, and with serum levels of PD-1/PD-L1, CTLA-4,
LAG-3, IL-6, and TNF-α. In parallel, VISTA tumor expression was evaluated in FMC samples.
The obtained data revealed that serum VISTA levels were significantly higher in cats presenting
HER2-positive (p = 0.0025) or triple-negative subtypes (p = 0.0019), with higher serum levels in
luminal A (p = 0.0025) correlated to the presence of metastasis (p = 0.0471). Furthermore, in HER2-
positive or triple-negative tumors, correlations were obtained between serum VISTA levels and the
serum levels of the above-mentioned molecules. In tumors, VISTA expression revealed a stronger
intensity in cancer cells, when compared to TILs (p < 0.0001). Stratifying the samples by subtypes, a
higher number of VISTA-positive TILs was observed in the HER2-positive subtype, compared with
triple-negative tumors (p = 0.0138). In conclusion, results support the development of therapeutic
strategies for HER2-positive and triple-negative FMC subtypes, reinforcing the use of cats as a human
oncology model.
Description
Research Areas: Oncology
Keywords
Feline mammary carcinoma Breast cancer VISTA Immune checkpoint Cancer model
Pedagogical Context
Citation
Gameiro A, Nascimento C, Correia J, Ferreira F. 2021. VISTA is a diagnostic biomarker and immunotherapy target of aggressive feline mammary carcinoma subtypes. Cancers, 13(21):5559. Doi: 10.3390/cancers13215559
Publisher
Universidade de Lisboa, Faculdade de Medicina Veterinária