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Contribution to the evaluation of the benefits of pergolide in the treatment of equine pituitary pars intermedia dysfunction (PPID) : reduction of helminth faecal egg counts (hFEC) and increased owner awareness

2023-11-06Master thesis Open access
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dc.contributor.advisorTilley, Paula Alexandra Botelho Garcia de Andrade Pimenta
dc.contributor.authorFerraz, Carolina Janeiro
dc.date.accessioned2023-12-11T17:08:09Z
dc.date.available2023-12-11T17:08:09Z
dc.date.issued2023-11-06
dc.descriptionDissertação de Mestrado Integrado em Medicina Veterinária, área científica de Clínicapt_PT
dc.description.abstractABSTRACT - CONTRIBUTION TO THE EVALUATION OF THE BENEFITS OF PERGOLIDE IN THE TREATMENT OF EQUINE PITUITARY PARS INTERMEDIA DYSFUNCTION (PPID): REDUCTION OF HELMINTH FAECAL EGG COUNTS (HFEC) AND INCREASED OWNER AWARENESS - Equine life expectancy is increasing and PPID is the most common endocrine disorder of older equids. The standard treatment is pergolide but PPID is often underdiagnosed as owners attribute its clinical manifestations to old age alone. Due to immunosuppression, these horses may have infections and higher helminth faecal egg counts (hFEC) and can require a more aggressive parasite control program. In the present study, fifteen horses were enrolled based on clinical examination and ACTH concentration. Ten of these were treated with pergolide (treatment group) and five received no medication (control group), in order to evaluate the effect of oral pergolide in the reduction of hFEC and time to egg reappearance over 6 months. Initially, all horses were de wormed and hFEC were carried out monthly over the study period. A questionnaire was also conducted, which was applied on days 1 and 180 of the study, with the aim of assessing awareness of the disease, and the owners' adherence to the treatment was recorded as well. Although not statistically significant, there were higher percentages of 0 EPG and fewer cases of clinically relevant values of EPG over the 5 evaluation periods in the treatment group when compared to the control group. The body condition score showed statistically significant differences between groups, being higher in the treatment group. Horses under pergolide treatment were better weight keepers, although without statistical significance. The influence of pergolide benefits in the quality of life of horses with PPID was reinforced, contributing to increase owner awareness of the disease. Owner adherence was 100%pt_PT
dc.description.abstractRESUMO - A expectativa de vida dos equinos tem vindo a aumentar e a disfunção da pars intermedia da pituitária (DPIP) é a doença endócrina mais comum em cavalos mais velhos. O tratamento padrão é baseado na administração de pergolida, no entanto a DPIP é frequentemente subdiagnosticada, já que os proprietários atribuem os seus sinais clínicos apenas ao envelhecimento. Devido à imunossupressão, esses cavalos podem ter infeções e contagens de ovos de helmintes nas fezes mais altas e podem requerer um programa de controlo de parasitas mais agressivo. No presente estudo, quinze cavalos foram escolhidos com base em exames clínicos e concentração de hormona adenocorticotrófica (ACTH). Dez deles foram tratados com pergolida (grupo de tratamento) e cinco não receberam medicação (grupo de controlo), de maneira a avaliar o efeito da pergolida oral na redução da contagem fecal de ovos de helmintes e no tempo de reaparecimento de ovos ao longo de 6 meses. Inicialmente, todos os cavalos foram desparasitados e as contagens foram realizadas mensalmente ao longo do período do estudo. Realizou-se ainda um questionário, que foi aplicado nos dias 1 e 180 do estudo, com o objetivo avaliar a consciencialização sobre a doença e registou-se também a adesão ao tratamento por parte dos proprietários. Embora não seja estatisticamente significativo, ao longo dos 5 períodos de avaliação houve maiores percentagens de 0 ovos por grama de fezes (OPG) e menos casos de valores clinicamente relevantes de OPG no grupo de tratamento quando comparados com o grupo de controlo. Relativamente à medição de condição corporal, esta mostrou diferenças estatisticamente significativas entre os grupos, sendo superior no grupo de tratamento. Cavalos sob tratamento com pergolida mantiveram melhores valores quanto ao peso, embora sem significância estatística. A influência dos benefícios da pergolida na qualidade de vida de cavalos com DPIP foi demonstrada, contribuindo para aumentar a consciencialização dos proprietários sobre a doença, tendo havido adesão total ao tratamento por parte dos proprietários dos animais em estudopt_PT
dc.description.versionN/Apt_PT
dc.identifier.citationFerraz CJ. 2023. Contribution to the evaluation of the benefits of pergolide in the treatment of equine pituitary pars intermedia dysfunction (PPID) : reduction of helminth faecal egg counts (hFEC) and increased owner awareness [dissertação de mestrado]. Lisboa: FMV-Universidade de Lisboapt_PT
dc.identifier.tid203441354
dc.identifier.urihttp://hdl.handle.net/10400.5/29578
dc.language.isoengpt_PT
dc.publisherUniversidade de Lisboa, Faculdade de Medicina Veterináriapt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectPPIDpt_PT
dc.subjectPergolidept_PT
dc.subjectFaecal egg countpt_PT
dc.subjectHorsept_PT
dc.subjectACTHpt_PT
dc.subjectDPIPpt_PT
dc.subjectPergolidapt_PT
dc.subjectContagem de ovos fecaispt_PT
dc.subjectEquinopt_PT
dc.subjectACTHpt_PT
dc.titleContribution to the evaluation of the benefits of pergolide in the treatment of equine pituitary pars intermedia dysfunction (PPID) : reduction of helminth faecal egg counts (hFEC) and increased owner awarenesspt_PT
dc.typemaster thesis
dspace.entity.typePublication
rcaap.rightsopenAccesspt_PT
rcaap.typemasterThesispt_PT

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