Publicação
Golimumab - anti-TNF monoclonal antibody: where we stand today
| dc.contributor.author | Melo, Ana Teresa | |
| dc.contributor.author | Campanilho-Marques, Raquel | |
| dc.contributor.author | Fonseca, João Eurico | |
| dc.date.accessioned | 2022-05-19T14:54:02Z | |
| dc.date.available | 2022-05-19T14:54:02Z | |
| dc.date.issued | 2020 | |
| dc.description | © 2020 Taylor & Francis Group, LLC | pt_PT |
| dc.description.abstract | Tumor necrosis factor (TNF) is a pro-inflammatory cytokine and its overexpression has been implicated in the pathophysiology of several chronic immune-mediated inflammatory diseases. Biological therapies, like TNF inhibitors, have been revolutionizing the course of these disorders. Golimumab is a transgenic anti-TNF monoclonal antibody that acts primarily by targeting and neutralizing TNF, thus preventing inflammation. It is approved for the treatment of Rheumatoid Arthritis, Psoriatic Arthritis, Ankylosing Spondylitis, Nonradiographic axial Spondyloarthritis, Juvenile Idiopathic Arthritis, and Ulcerative Colitis. Clinical trials are also being conducted in other conditions. This review charts the clinical development of golimumab and outlines the data that support its potential use across several Immune-mediated inflammatory diseases. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.citation | Hum Vaccin Immunother. 2021 Jun 3;17(6):1586-1598 | pt_PT |
| dc.identifier.doi | 10.1080/21645515.2020.1836919 | pt_PT |
| dc.identifier.eissn | 2164-554X | |
| dc.identifier.issn | 2164-5515 | |
| dc.identifier.uri | http://hdl.handle.net/10451/53078 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.publisher | Taylor & Francis | pt_PT |
| dc.relation.publisherversion | https://www.tandfonline.com/journals/khvi20 | pt_PT |
| dc.subject | Immune-mediated inflammatory diseases | pt_PT |
| dc.subject | Golimumab | pt_PT |
| dc.subject | Tnf inhibitors | pt_PT |
| dc.title | Golimumab - anti-TNF monoclonal antibody: where we stand today | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 1598 | pt_PT |
| oaire.citation.issue | 6 | pt_PT |
| oaire.citation.startPage | 1586 | pt_PT |
| oaire.citation.title | Human Vaccines & Immunotherapeutics | pt_PT |
| oaire.citation.volume | 17 | pt_PT |
| person.familyName | Melo | |
| person.familyName | Campanilho-Marques | |
| person.familyName | Fonseca | |
| person.givenName | Ana Teresa | |
| person.givenName | Raquel | |
| person.givenName | João | |
| person.identifier.ciencia-id | FB1D-B9BA-5204 | |
| person.identifier.ciencia-id | F310-B85D-57C7 | |
| person.identifier.orcid | 0000-0002-7904-0683 | |
| person.identifier.orcid | 0000-0002-1894-8516 | |
| person.identifier.orcid | 0000-0003-1432-3671 | |
| person.identifier.scopus-author-id | 7101983519 | |
| rcaap.rights | restrictedAccess | pt_PT |
| rcaap.type | article | pt_PT |
| relation.isAuthorOfPublication | f7c2f8ee-54b9-40d6-a39a-a31083a5f193 | |
| relation.isAuthorOfPublication | 324a51d2-4ed3-428e-aeb8-0c470a05324d | |
| relation.isAuthorOfPublication | 1772dc12-7c55-4c76-ae2d-c23270172480 | |
| relation.isAuthorOfPublication.latestForDiscovery | f7c2f8ee-54b9-40d6-a39a-a31083a5f193 |
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