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Publicação
Golimumab - anti-TNF monoclonal antibody: where we stand today
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Orientador(es)
Resumo(s)
Tumor necrosis factor (TNF) is a pro-inflammatory cytokine and its overexpression has been implicated in the pathophysiology of several chronic immune-mediated inflammatory diseases. Biological therapies, like TNF inhibitors, have been revolutionizing the course of these disorders. Golimumab is a transgenic anti-TNF monoclonal antibody that acts primarily by targeting and neutralizing TNF, thus preventing inflammation. It is approved for the treatment of Rheumatoid Arthritis, Psoriatic Arthritis, Ankylosing Spondylitis, Nonradiographic axial Spondyloarthritis, Juvenile Idiopathic Arthritis, and Ulcerative Colitis. Clinical trials are also being conducted in other conditions. This review charts the clinical development of golimumab and outlines the data that support its potential use across several Immune-mediated inflammatory diseases.
Descrição
© 2020 Taylor & Francis Group, LLC
Palavras-chave
Immune-mediated inflammatory diseases Golimumab Tnf inhibitors
Contexto Educativo
Citação
Hum Vaccin Immunother. 2021 Jun 3;17(6):1586-1598
Editora
Taylor & Francis