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Is the calcium sensing receptor a phosphocalcic sensor?
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Resumo(s)
Breast and prostate cancers are the most frequent forms of cancer and there is an unquestioned correlation between them and the appearance of a secondary bone tumour. The bone environment is believed to be favourable for the development of breast and prostate cancer's metastasis, due to bone-derived factors released during bone turnover that attract cancer cells, enabling metastasis and growth. Once tumours metastasize to bone, they are virtually incurable. (1), so it is vital and urgent to know which are the mechanisms behind this bone tropic tumour cells. In the majority of breast and prostate cancer's cells, the Calcium Sensing Receptor is overexpressed. A research was started about the possible interaction/relation between Calcium Sensing Receptors (CaSR) and the Calcium/Phosphate Complexes of Hydroxyapatite. As it was in a very early first stage, the starting point of the investigation were three experiments that in three different ways could help making a bridge between the receptor sensitive to Calcium and the bone's Phosphocalcic Complexes. The protocols were based on other similar experiments although not quite the same, so they were adapted and established to the new conditions.
Descrição
Trabalho Final de Mestrado Integrado, Ciências Farmacêuticas, Universidade de Lisboa, Faculdade de Farmácia, 2015
Palavras-chave
Bone Metastasis Calcium Calcium Sensing Receptor Calcium-Phosphate Sensing Receptor Hydroxyapatite Mestrado Integrado - 2015