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Ensaio de utilização de Tulatromicina em borregos de feedlot
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A profilaxia sempre se mostrou eficaz na prevenção da morbilidade e mortalidade por
doença respiratória, em vitelos de feedlots, no entanto, o estudo desta aplicação em borregos,
no mesmo regime, não é comum.
Este estudo prospetivo teve como objetivo perceber a eficácia da aplicação profilática
de tulatromicina nesta espécie e avaliar, simultaneamente, qual a altura mais eficaz para essa
administração. Também serviu para concluir se o uso profilático de antimicrobianos se reflete
numa melhoria dos indicadores produtivos, tema sobre o qual alguns estudos divergem.
O ensaio foi realizado pelo gestor do feedlot durante o verão, altura em que as taxas
de mortalidade neste feedlot aumentavam devido ao stress por calor, e contou com a inclusão
de 2235 animais. Foi administrado Draxxin® 100 mg/ml, na dose de 2,5 mg de tulatromicina/kg
de peso corporal a 1132 animais (50,6%). Os restantes animais não receberam qualquer
tratamento (grupo controlo). A amostra de animais foi dividida em 3 subgrupos consoante a
altura de aplicação do tratamento profilático: se ocorreu à chegada (subgrupo 0), 1 dia
(subgrupo 1) ou 2 ou 3 dias após a chegada (subgrupo 2).
A tulatromicina mostrou ter um efeito positivo na redução de mortalidade associada a
doença respiratória em borregos, tanto pela redução observada na taxa de mortalidade (de
11,88% para 7,24%; P<0,001), como pelo aumento do intervalo chegada-morte: os animais
tratados apresentaram uma diferença no intervalo chegada-morte 3,1 dias superior aos
animais não tratados (P = 0,012). Observou-se também que a altura de aplicação mais eficaz
mostrou ser à chegada dos animais ao feedlot, pois foi onde houve a maior redução na taxa
de mortalidade entre grupo tratado e grupo controlo (6,59 pontos percentuais; P<0,001). No
entanto, a altura de aplicação do tratamento já não pareceu influenciar o intervalo chegada morte (P = 0,182).
Apesar de ter sido possível observar diferenças nas mortalidades consoante a origem
dos animais, não foi possível estabelecer uma relação estatisticamente significativa, por
ausência de um teste estatístico válido.
A falta de diferenças estatisticamente relevantes entre as médias relativas ao peso
vivo (P = 0,277), ganho médio diário (P = 0,396) e ganho de peso vivo total (P = 0,166), no
grupo tratado, controlo e nos 3 subgrupos criados (P = 0,347; P = 0,513; P = 0,606), indica
que a profilaxia e a altura da sua aplicação não têm impacto nos indicadores produtivos
ABSTRACT - TULATHROMYCIN TRIAL IN FEEDLOT LAMBS - Prophylaxis has always proved to be effective in preventing morbidity and mortality from respiratory disease in feedlot calves however, the study of this application in feedlot lambs is not common. This prospective study aimed to understand the effectiveness of the prophylactic application of tulathromycin in this species and simultaneously evaluate the most effective time for administration. It also served to evaluate whether the prophylactic use of antimicrobials is reflected in an improvement in performance indicators, a topic on which some studies differ. The trial was carried out by the feedlot manager during the summer, when mortality rates in this feedlot increased due to heat stress, and involved 2235 animals. Draxxin® 100 mg/ml, at a dose of 2,5 mg of tulathromycin/kg of body weight, was administered to 1132 animals (50,6%). The remaining animals received no treatment (control group). The animal sample was divided into 3 subgroups according to the time of administration of the prophylactic treatment: whether it occurred on arrival (subgroup 0), 1 day (subgroup 1) or 2 or 3 days after arrival (subgroup 2). Tulathromycin was shown to have a favorable effect in reducing mortality associated with respiratory disease in lambs, both due to the observed reduction in the mortality rate (from 11,88% to 7,24%; P<0,001), and in the increase in the arrival-death interval: the treated animals showed a difference in the arrival-death interval 3,1 days higher than the untreated animals (P = 0,012). The timing of the most effective application proved to be when the animals arrived at the feedlot, as this was where there was the greatest reduction in the mortality rate between the treated and control groups (6,59 percentage points; P<0,001). The timing of treatment administration did not appear to influence the arrival-death interval (P = 0,182). Although it was possible to observe differences in mortalities according to the origin of the animals, it was not possible to establish a statistically significant relationship, due to the absence of a valid statistical test. The lack of statistically relevant differences between the means relative to live weight (P = 0,277), average daily gain (P = 0,396) and total live weight gain (P = 0,166), in the treated group, control and in the 3 subgroups created (P = 0,347; P = 0,513; P = 0,606), indicates that prophylaxis and the timing of its administration does not have an impact on performance indicators
ABSTRACT - TULATHROMYCIN TRIAL IN FEEDLOT LAMBS - Prophylaxis has always proved to be effective in preventing morbidity and mortality from respiratory disease in feedlot calves however, the study of this application in feedlot lambs is not common. This prospective study aimed to understand the effectiveness of the prophylactic application of tulathromycin in this species and simultaneously evaluate the most effective time for administration. It also served to evaluate whether the prophylactic use of antimicrobials is reflected in an improvement in performance indicators, a topic on which some studies differ. The trial was carried out by the feedlot manager during the summer, when mortality rates in this feedlot increased due to heat stress, and involved 2235 animals. Draxxin® 100 mg/ml, at a dose of 2,5 mg of tulathromycin/kg of body weight, was administered to 1132 animals (50,6%). The remaining animals received no treatment (control group). The animal sample was divided into 3 subgroups according to the time of administration of the prophylactic treatment: whether it occurred on arrival (subgroup 0), 1 day (subgroup 1) or 2 or 3 days after arrival (subgroup 2). Tulathromycin was shown to have a favorable effect in reducing mortality associated with respiratory disease in lambs, both due to the observed reduction in the mortality rate (from 11,88% to 7,24%; P<0,001), and in the increase in the arrival-death interval: the treated animals showed a difference in the arrival-death interval 3,1 days higher than the untreated animals (P = 0,012). The timing of the most effective application proved to be when the animals arrived at the feedlot, as this was where there was the greatest reduction in the mortality rate between the treated and control groups (6,59 percentage points; P<0,001). The timing of treatment administration did not appear to influence the arrival-death interval (P = 0,182). Although it was possible to observe differences in mortalities according to the origin of the animals, it was not possible to establish a statistically significant relationship, due to the absence of a valid statistical test. The lack of statistically relevant differences between the means relative to live weight (P = 0,277), average daily gain (P = 0,396) and total live weight gain (P = 0,166), in the treated group, control and in the 3 subgroups created (P = 0,347; P = 0,513; P = 0,606), indicates that prophylaxis and the timing of its administration does not have an impact on performance indicators
Descrição
Dissertação de Mestrado Integrado em Medicina Veterinária, na área científica de Clínica
Palavras-chave
Profilaxia Tulatromicina Doença respiratória Feedlots Borregos Prophylaxis Tulathromycin Respiratory disease Feedlots Lambs
Contexto Educativo
Citação
Cabral MJS. 2023. Ensaio de utilização de Tulatromicina em borregos de feedlot [dissertação de mestrado]. Lisboa: FMV-Universidade de Lisboa
Editora
Universidade de Lisboa, Faculdade de Medicina Veterinária